DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VTETPPIT
Uniprot ID:
A6NF01
Source protein:
Putative nuclear envelope pore membrane protein POM 121B
Source gene:
POM121B
Class:
DEG_SCF_FBW7_1
Location:
146:153
E3 ligase:
FBXW7
DEGRON score:
0.9873
ASA_SCORE:
95.6375
COIL:
0.9538
CONS_SCORE:
0.2634
DSS_SCORE:
0.5585
HELIX:
0.0168
FCONS_SCORE:
1.128
RIG_SCORE:
0.6709
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with POM121B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTETPPIT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96HA1
Nuclear envelope pore membrane protein POM 121
DEG_SCF_FBW7_1
562:569
VTETPPIT
FBXW7
0.9827
More...
A6NF01
Putative nuclear envelope pore membrane protein POM 121B
DEG_SCF_FBW7_1
146:153
VTETPPIT
FBXW7
0.9873
More...