DegronMD

Uniprot ID: Q9BX66

Source protein: Sorbin and SH3 domain-containing protein 1

Source gene: SORBS1

Class: DEG_SCF_FBW7_1

Location: 639:646

E3 ligase: FBXW7

DEGRON score: 0.9941

ASA_SCORE: 63.925

COIL: 0.9139

CONS_SCORE: 0.2435

DSS_SCORE: 0.5824

HELIX: 0.0283

FCONS_SCORE: 0.6271

RIG_SCORE: 0.6327

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A638V	TCGA-EB-A6QY	SKCM	TCGA	ISPTPEIS	DEG_SCF_FBW7_1	0.3056
p.S655Y	TCGA-F5-6814	READ	TCGA	ISPTPEIS	DEG_SCF_FBW7_1	0.0833
p.S634F	DO229048	LICA	ICGC	ISPTPEIS	DEG_SCF_FBW7_1	0.1944
p.P629L	SIDM00489	Oral Cavity Carcinoma	GDSC	ISPTPEIS	DEG_SCF_FBW7_1	0.0556
p.P629L	ACH-002043	Head and Neck Cancer	CCLE	ISPTPEIS	DEG_SCF_FBW7_1	0.0556
p.P629L	Ca9-22	upper_aerodigestive_tract	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	0.0556
p.R648W	ACH-000847	Gastric Cancer	CCLE	ISPTPEIS	DEG_SCF_FBW7_1	0.2778
p.R648W	HGC-27	stomach	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	0.2778
p.G637R	DMS-53	lung	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	0.2778
p.K649R	DU-145	prostate	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	0.25
p.T646M	COLO-320-HSR	large_intestine	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	0.7423
p.T646M	CAKI-1	kidney	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	0.7423
p.T643A	SNU-C5	large_intestine	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	0.7139
p.P651L	Ca9-22	upper_aerodigestive_tract	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	0.1944
p.H629R	SW620	large_intestine	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	0.0556
p.H629R	HH	haematopoietic_and_lymphoid_tissue	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	0.0556
p.Y632H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	0.1389
p.F655C	HCC2998	large_intestine	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	0.0833
p.S642F	Sarc9371	bone	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SCF_FBW7_1	639:646	ISPTPEIS	FBXW7	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons