DegronMD

Uniprot ID: P10070

Source protein: Zinc finger protein GLI2

Source gene: GLI2

Class: DEG_SCF_FBW7_1

Location: 221:228

E3 ligase: FBXW7

DEGRON score: 0.9565

ASA_SCORE: 100.675

COIL: 0.8635

CONS_SCORE: 0.5121

DSS_SCORE: 0.4095

HELIX: 0.1004

FCONS_SCORE: 0.9441

RIG_SCORE: 0.7153

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L227M	TCGA-78-7145	LUAD	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.5999
p.L227M	DO26374	LUAD	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.5999
p.T224M	TCGA-A5-A1OF	UCEC	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.8534
p.T224M	TCGA-BR-8368	STAD	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.8534
p.T224M	DO47981	STAD	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.8534
p.T224M	DO42568	UCEC	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.8534
p.R229C	TCGA-D5-6928	COAD	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229C	DO7776	COAD	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R222W	TCGA-DD-A11A	LIHC	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.7523
p.R222W	DO22835	LIHC	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.7523
p.R222W	SIDM01735	Biliary Tract Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	0.7523
p.R222W	ACH-000808	Bile Duct Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	0.7523
p.P221S	TCGA-FW-A5DY	SKCM	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.6752
p.P221S	DO47257	SKCM	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.6752
p.R229H	TCGA-HC-7749	PRAD	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229H	DO36242	PRAD	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229H	SIDM01943	Colorectal Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229H	SIDM00487	Colorectal Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229H	SIDM01729	Endometrial Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229H	ACH-000909	Endometrial/Uterine Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229H	ACH-000963	Colon/Colorectal Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229H	CCK-81	large_intestine	COSMIC	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R217H	TCGA-K4-A54R	BLCA	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.2222
p.R217H	DO48611	BLCA	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.2222
p.R217H	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	0.2222
p.R217H	ACH-000662	Lung Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	0.2222
p.P221L	TCGA-XF-A9T8	BLCA	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.6471
p.P221L	DO51927	BLCA	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.6471
p.P221A	DO222461	BTCA	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.7503
p.P212L	DO222875	MELA	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.0833
p.V213M	SIDM00367	Small Cell Lung Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	0.1111
p.V213M	SIDM00556	Neuroblastoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	0.1111
p.V213M	SIDM00836	Colorectal Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	0.1111
p.V213M	KP-N-YN	autonomic_ganglia	COSMIC	PRVTPRLS	DEG_SCF_FBW7_1	0.1111
p.V213M	SBC-3	lung	COSMIC	PRVTPRLS	DEG_SCF_FBW7_1	0.1111
p.A232P	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	0.2222
p.A232P	ACH-000892	Lung Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	0.2222
p.A232P	NCI-H1563	lung	COSMIC	PRVTPRLS	DEG_SCF_FBW7_1	0.2222
p.A232V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	0.2222
p.A232V	ACH-000920	Leukemia	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	0.2222
p.A232V	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PRVTPRLS	DEG_SCF_FBW7_1	0.2222
p.P225S	ACH-000501	Colon/Colorectal Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	0.6752
p.P225S	LS-123	large_intestine	COSMIC	PRVTPRLS	DEG_SCF_FBW7_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRVTPRLS

Degron related mutations and impact score

Drug responses associated with GLI2 mutations

All proteins holding degron of PRVTPRLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10070	Zinc finger protein GLI2	DEG_SCF_FBW7_1	221:228	PRVTPRLS	FBXW7	0.9565	More...