DegronMD

Uniprot ID: P10070

Source protein: Zinc finger protein GLI2

Source gene: GLI2

Class: DEG_SCF_FBW7_1

Location: 221:228

E3 ligase: FBXW7

DEGRON score: 0.9565

ASA_SCORE: 100.675

COIL: 0.8635

CONS_SCORE: 0.5121

DSS_SCORE: 0.4095

HELIX: 0.1004

FCONS_SCORE: 0.9441

RIG_SCORE: 0.7153

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T224M	TCGA-A5-A1OF	UCEC	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.8534
p.T224M	TCGA-BR-8368	STAD	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.8534
p.T224M	DO47981	STAD	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.8534
p.T224M	DO42568	UCEC	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.8534
p.R222W	TCGA-DD-A11A	LIHC	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.7523
p.R222W	DO22835	LIHC	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.7523
p.R222W	SIDM01735	Biliary Tract Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	0.7523
p.R222W	ACH-000808	Bile Duct Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	0.7523
p.P221A	DO222461	BTCA	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.7503
p.P221S	TCGA-FW-A5DY	SKCM	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.6752
p.P221S	DO47257	SKCM	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.6752
p.P225S	ACH-000501	Colon/Colorectal Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	0.6752
p.P225S	LS-123	large_intestine	COSMIC	PRVTPRLS	DEG_SCF_FBW7_1	0.6752
p.P221L	TCGA-XF-A9T8	BLCA	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.6471
p.P221L	DO51927	BLCA	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.6471
p.L227M	TCGA-78-7145	LUAD	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.5999
p.L227M	DO26374	LUAD	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.5999
p.R229C	TCGA-D5-6928	COAD	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229C	DO7776	COAD	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229H	TCGA-HC-7749	PRAD	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229H	DO36242	PRAD	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229H	SIDM01943	Colorectal Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229H	SIDM00487	Colorectal Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229H	SIDM01729	Endometrial Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	0.3056
p.R229H	ACH-000909	Endometrial/Uterine Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	0.3056

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Drug responses associated with GLI2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PRVTPRLS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10070	Zinc finger protein GLI2	DEG_SCF_FBW7_1	221:228	PRVTPRLS	FBXW7	0.9565	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRVTPRLS

Degron related mutations and impact score

Drug responses associated with GLI2 mutations

All proteins holding degron of PRVTPRLS