DegronMD

Uniprot ID: P10070

Source protein: Zinc finger protein GLI2

Source gene: GLI2

Class: LIG_APCC_ABBA_1

Location: 122:127

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9835

ASA_SCORE: 60.3667

COIL: 0.5842

CONS_SCORE: 0.4104

DSS_SCORE: 0.4293

HELIX: 0.384

FCONS_SCORE: 1.0463

RIG_SCORE: 0.6804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P120Q	TCGA-05-4427	LUAD	TCGA	VNPHME	LIG_APCC_ABBA_1	0.2778
p.P120Q	DO23666	LUAD	ICGC	VNPHME	LIG_APCC_ABBA_1	0.2778
p.E112K	TCGA-12-0820	GBM	TCGA	VNPHME	LIG_APCC_ABBA_1	0.0556
p.E112K	DO12838	GBM	ICGC	VNPHME	LIG_APCC_ABBA_1	0.0556
p.Y129F	TCGA-17-Z055	LUAD	TCGA	VNPHME	LIG_APCC_ABBA_1	0.2778
p.S132Y	TCGA-FU-A3HZ	CESC	TCGA	VNPHME	LIG_APCC_ABBA_1	0.6389
p.S132Y	DO6308	CESC	ICGC	VNPHME	LIG_APCC_ABBA_1	0.6389
p.P118L	DO233748	GACA	ICGC	VNPHME	LIG_APCC_ABBA_1	0.2222
p.R131L	DO229028	LICA	ICGC	VNPHME	LIG_APCC_ABBA_1	0.2222
p.S113Y	DO50974	LICA	ICGC	VNPHME	LIG_APCC_ABBA_1	0.0833
p.H119Y	DO220884	MELA	ICGC	VNPHME	LIG_APCC_ABBA_1	0.25
p.H119N	SIDM00391	Plasma Cell Myeloma	GDSC	VNPHME	LIG_APCC_ABBA_1	0.25
p.H119N	ACH-000363	Myeloma	CCLE	VNPHME	LIG_APCC_ABBA_1	0.25
p.H119N	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VNPHME	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10070	Zinc finger protein GLI2	LIG_APCC_ABBA_1	122:127	VNPHME	APC,CDC20,FZR1	0.9835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons