DegronMD

Uniprot ID: Q7Z5N4

Source protein: Protein sidekick-1

Source gene: SDK1

Class: DEG_SCF_FBW7_1

Location: 1585:1592

E3 ligase: FBXW7

DEGRON score: 0.7594

ASA_SCORE: 51.45

COIL: 0.4159

CONS_SCORE: 0.4996

DSS_SCORE: 0.6035

HELIX: 0.0063

FCONS_SCORE: 0.8877

RIG_SCORE: 0.6401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1600H	TCGA-09-2044	OV	TCGA	VSATPHTT	DEG_SCF_FBW7_1	0.1111
p.Q1600H	DO229045	LICA	ICGC	VSATPHTT	DEG_SCF_FBW7_1	0.1111
p.Q1600H	DO28923	OV	ICGC	VSATPHTT	DEG_SCF_FBW7_1	0.1111
p.A1587T	TCGA-B5-A5OC	UCEC	TCGA	VSATPHTT	DEG_SCF_FBW7_1	0.6028
p.A1587T	DO52405	UCEC	ICGC	VSATPHTT	DEG_SCF_FBW7_1	0.6028
p.P1602Q	TCGA-BR-4362	STAD	TCGA	VSATPHTT	DEG_SCF_FBW7_1	0.0556
p.P1602Q	DO38336	STAD	ICGC	VSATPHTT	DEG_SCF_FBW7_1	0.0556
p.S1594F	TCGA-D3-A2JP	SKCM	TCGA	VSATPHTT	DEG_SCF_FBW7_1	0.2778
p.S1594F	DO47407	SKCM	ICGC	VSATPHTT	DEG_SCF_FBW7_1	0.2778
p.P1602L	TCGA-DC-6158	READ	TCGA	VSATPHTT	DEG_SCF_FBW7_1	0.0556
p.P1602L	DO37197	READ	ICGC	VSATPHTT	DEG_SCF_FBW7_1	0.0556
p.P1602L	SIDM01060	Melanoma	GDSC	VSATPHTT	DEG_SCF_FBW7_1	0.0556
p.P1602L	IGR-1	skin	COSMIC	VSATPHTT	DEG_SCF_FBW7_1	0.0556
p.A1587V	TCGA-E6-A1LX	UCEC	TCGA	VSATPHTT	DEG_SCF_FBW7_1	0.5825
p.A1587V	DO41020	UCEC	ICGC	VSATPHTT	DEG_SCF_FBW7_1	0.5825
p.A1587V	SIDM02030	Colorectal Carcinoma	GDSC	VSATPHTT	DEG_SCF_FBW7_1	0.5825
p.P1578S	TCGA-FW-A3R5	SKCM	TCGA	VSATPHTT	DEG_SCF_FBW7_1	0.1389
p.P1578S	DO37406	SKCM	ICGC	VSATPHTT	DEG_SCF_FBW7_1	0.1389
p.E1580G	DO229229	THCA	ICGC	VSATPHTT	DEG_SCF_FBW7_1	0.1944
p.A1587G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VSATPHTT	DEG_SCF_FBW7_1	0.6429
p.A1587G	H513	pleura	COSMIC	VSATPHTT	DEG_SCF_FBW7_1	0.6429

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5N4	Protein sidekick-1	DEG_SCF_FBW7_1	1585:1592	VSATPHTT	FBXW7	0.7594	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons