DegronMD

Uniprot ID: Q7Z5N4

Source protein: Protein sidekick-1

Source gene: SDK1

Class: DEG_APCC_DBOX_1

Location: 601:609

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5201

ASA_SCORE: 52.1444

COIL: 0.3708

CONS_SCORE: 0.4011

DSS_SCORE: 0.2542

HELIX: 0.0114

FCONS_SCORE: 0.9084

RIG_SCORE: 0.8684

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R606L	TCGA-49-AAR2	LUAD	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	0.7316
p.R606L	DO218918	LUAD	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	0.7316
p.D600E	TCGA-55-8511	LUAD	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	0.3056
p.D600E	DO24940	LUAD	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	0.3056
p.V608I	TCGA-AX-A2HC	UCEC	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	0.5965
p.V608I	DO41572	UCEC	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	0.5965
p.V608I	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRVSLRYVW	DEG_APCC_DBOX_1	0.5965
p.V608I	ACH-000073	Lymphoma	CCLE	PRVSLRYVW	DEG_APCC_DBOX_1	0.5965
p.V608I	GRANTA-519	haematopoietic_and_lymphoid_tissue	COSMIC	PRVSLRYVW	DEG_APCC_DBOX_1	0.5965
p.R606C	TCGA-B6-A0IC	BRCA	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	0.719
p.R606C	DO4928	BRCA	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	0.719
p.T598A	TCGA-CG-4306	STAD	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	0.25
p.T598A	DO38567	STAD	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	0.25
p.T592M	TCGA-FP-A4BF	STAD	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	0.0833
p.T592M	DO50447	ESAD	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	0.0833
p.T592M	DO47775	STAD	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	0.0833
p.R602W	TCGA-O1-A52J	LUAD	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	0.8634
p.R602W	DO218948	LUAD	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	0.8634
p.D600Y	TCGA-YC-A8S6	BLCA	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	0.3056
p.D600Y	DO49806	BLCA	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	0.3056
p.A591D	DO230315	COCA	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	0.0556
p.D600G	DO23192	LINC	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	0.3056
p.N613S	SIDM01129	Small Cell Lung Carcinoma	GDSC	PRVSLRYVW	DEG_APCC_DBOX_1	0.2222
p.S604L	SIDM01622	Breast Carcinoma	GDSC	PRVSLRYVW	DEG_APCC_DBOX_1	0.6556
p.S604L	ACH-000721	Breast Cancer	CCLE	PRVSLRYVW	DEG_APCC_DBOX_1	0.6556
p.G596V	SIDM01619	Endometrial Carcinoma	GDSC	PRVSLRYVW	DEG_APCC_DBOX_1	0.1944
p.G596V	ACH-000984	Endometrial/Uterine Cancer	CCLE	PRVSLRYVW	DEG_APCC_DBOX_1	0.1944
p.H594R	ACH-000990	Endometrial/Uterine Cancer	CCLE	PRVSLRYVW	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRVSLRYVW

Degron related mutations and impact score

Drug responses associated with SDK1 mutations

All proteins holding degron of PRVSLRYVW

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5N4	Protein sidekick-1	DEG_APCC_DBOX_1	601:609	PRVSLRYVW	APC,CDC20,FZR1	0.5201	More...