DegronMD

Uniprot ID: Q7Z5N4

Source protein: Protein sidekick-1

Source gene: SDK1

Class: DEG_SPOP_SBC_1

Location: 1589:1593

E3 ligase: SPOP

DEGRON score: 0.8702

ASA_SCORE: 66.58

COIL: 0.6872

CONS_SCORE: 0.4886

DSS_SCORE: 0.5292

HELIX: 0.009

FCONS_SCORE: 0.8747

RIG_SCORE: 0.694

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1600H	TCGA-09-2044	OV	TCGA	PHTTS	DEG_SPOP_SBC_1	0.1389
p.Q1600H	DO229045	LICA	ICGC	PHTTS	DEG_SPOP_SBC_1	0.1389
p.Q1600H	DO28923	OV	ICGC	PHTTS	DEG_SPOP_SBC_1	0.1389
p.P1602Q	TCGA-BR-4362	STAD	TCGA	PHTTS	DEG_SPOP_SBC_1	0.0833
p.P1602Q	DO38336	STAD	ICGC	PHTTS	DEG_SPOP_SBC_1	0.0833
p.S1594F	TCGA-D3-A2JP	SKCM	TCGA	PHTTS	DEG_SPOP_SBC_1	0.3056
p.S1594F	DO47407	SKCM	ICGC	PHTTS	DEG_SPOP_SBC_1	0.3056
p.P1602L	TCGA-DC-6158	READ	TCGA	PHTTS	DEG_SPOP_SBC_1	0.0833
p.P1602L	DO37197	READ	ICGC	PHTTS	DEG_SPOP_SBC_1	0.0833
p.P1602L	SIDM01060	Melanoma	GDSC	PHTTS	DEG_SPOP_SBC_1	0.0833
p.P1602L	IGR-1	skin	COSMIC	PHTTS	DEG_SPOP_SBC_1	0.0833
p.E1580G	DO229229	THCA	ICGC	PHTTS	DEG_SPOP_SBC_1	0.0833
p.S1593F	SIDM00955	Melanoma	GDSC	PHTTS	DEG_SPOP_SBC_1	0.7982
p.S1593F	ACH-000812	Skin Cancer	CCLE	PHTTS	DEG_SPOP_SBC_1	0.7982
p.S1593F	COLO-783	skin	COSMIC	PHTTS	DEG_SPOP_SBC_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	846:850	PHTTS	SPOP	0.9409	More...
Q7Z5N4	Protein sidekick-1	DEG_SPOP_SBC_1	1589:1593	PHTTS	SPOP	0.8702	More...
Q9H8J5	MANSC domain-containing protein 1	DEG_SPOP_SBC_1	235:239	PHTTS	SPOP	0.9619	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons