DegronMD

Uniprot ID: O43166

Source protein: Signal-induced proliferation-associated 1-like protein 1

Source gene: SIPA1L1

Class: DEG_APCC_DBOX_1

Location: 163:171

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7911

ASA_SCORE: 98.2

COIL: 0.4816

CONS_SCORE: 0.4096

DSS_SCORE: 0.5345

HELIX: 0.4981

FCONS_SCORE: 0.9569

RIG_SCORE: 0.7337

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S162A	TCGA-17-Z022	LUAD	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	0.75
p.S174N	TCGA-A6-6781	COAD	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	0.6944
p.S174N	DO8447	COAD	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.6944
p.R171H	TCGA-B5-A3FA	UCEC	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	0.7133
p.R171H	TCGA-DI-A1BU	UCEC	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	0.7133
p.R171H	DO42023	UCEC	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.7133
p.R171H	DO52402	UCEC	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.7133
p.M155I	TCGA-BR-6452	STAD	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	0.1111
p.M155I	DO38404	STAD	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.1111
p.R168C	TCGA-BR-6801	STAD	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	0.719
p.R168C	TCGA-D1-A103	UCEC	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	0.719
p.R168C	TCGA-D3-A3C8	SKCM	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	0.719
p.R168C	DO47636	SKCM	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.719
p.R168C	DO38253	STAD	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.719
p.R168C	DO42312	UCEC	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.719
p.A158T	TCGA-CD-A4MG	STAD	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	0.1944
p.A158T	DO48009	STAD	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.1944
p.P160H	TCGA-ER-A2NH	SKCM	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	0.25
p.P160H	DO47683	SKCM	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.25
p.R173Q	TCGA-VS-A959	CESC	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	0.2778
p.R173Q	DO51640	CESC	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.2778
p.S162C	DO2287	BRCA	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.75
p.R171C	DO227987	COCA	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.719
p.R168H	DO222884	COCA	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.7133
p.S162F	DO229177	LMS	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.75
p.S174C	DO224563	LUSC	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.6944
p.P169L	DO50288	SKCM	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	0.7582
p.S176I	SIDM00683	Prostate Carcinoma	GDSC	PRKALRRIR	DEG_APCC_DBOX_1	0.6389
p.S176I	ACH-000977	lymph_node	CCLE	PRKALRRIR	DEG_APCC_DBOX_1	0.6389
p.S176I	LNCaP-Clone-FGC	prostate	COSMIC	PRKALRRIR	DEG_APCC_DBOX_1	0.6389
p.E157K	SIDM00905	Cervical Carcinoma	GDSC	PRKALRRIR	DEG_APCC_DBOX_1	0.1667
p.E157K	ACH-001334	Cervical Cancer	CCLE	PRKALRRIR	DEG_APCC_DBOX_1	0.1667
p.E157K	ACH-001335	Cervical Cancer	CCLE	PRKALRRIR	DEG_APCC_DBOX_1	0.1667
p.E157K	C-4-I	cervix	COSMIC	PRKALRRIR	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRKALRRIR

Degron related mutations and impact score

Drug responses associated with SIPA1L1 mutations

All proteins holding degron of PRKALRRIR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43166	Signal-induced proliferation-associated 1-like protein 1	DEG_APCC_DBOX_1	163:171	PRKALRRIR	APC,CDC20,FZR1	0.7911	More...