DegronMD

Uniprot ID: Q9ULT8

Source protein: E3 ubiquitin-protein ligase HECTD1

Source gene: HECTD1

Class: DEG_SCF_FBW7_1

Location: 1470:1476

E3 ligase: FBXW7

DEGRON score: 0.9736

ASA_SCORE: 84.5571

COIL: 0.8989

CONS_SCORE: 0.3411

DSS_SCORE: 0.5904

HELIX: 0.058

FCONS_SCORE: 0.9691

RIG_SCORE: 0.6338

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1471C	TCGA-AN-A046	BRCA	TCGA	VRTPGES	DEG_SCF_FBW7_1	0.719
p.R1471C	DO1285	BRCA	ICGC	VRTPGES	DEG_SCF_FBW7_1	0.719
p.R1471C	DO227999	COCA	ICGC	VRTPGES	DEG_SCF_FBW7_1	0.719
p.R1471C	DO46352	OV	ICGC	VRTPGES	DEG_SCF_FBW7_1	0.719
p.G1465D	TCGA-AZ-4315	COAD	TCGA	VRTPGES	DEG_SCF_FBW7_1	0.1944
p.G1465D	DO8842	COAD	ICGC	VRTPGES	DEG_SCF_FBW7_1	0.1944
p.P1466S	TCGA-ER-A19G	SKCM	TCGA	VRTPGES	DEG_SCF_FBW7_1	0.2222
p.P1466S	DO47284	SKCM	ICGC	VRTPGES	DEG_SCF_FBW7_1	0.2222
p.E1461K	TCGA-XF-A9SM	BLCA	TCGA	VRTPGES	DEG_SCF_FBW7_1	0.0833
p.E1461K	DO223597	BLCA	ICGC	VRTPGES	DEG_SCF_FBW7_1	0.0833
p.T1472I	DO233871	GACA	ICGC	VRTPGES	DEG_SCF_FBW7_1	0.8189
p.R1471H	DO229569	PRAD	ICGC	VRTPGES	DEG_SCF_FBW7_1	0.7133
p.A1478T	SIDM00173	Head and Neck Carcinoma	GDSC	VRTPGES	DEG_SCF_FBW7_1	0.2778
p.A1478T	ACH-000618	Head and Neck Cancer	CCLE	VRTPGES	DEG_SCF_FBW7_1	0.2778
p.M1481V	SIDM01694	B-Lymphoblastic Leukemia	GDSC	VRTPGES	DEG_SCF_FBW7_1	0.1944
p.M1481V	ACH-000728	Leukemia	CCLE	VRTPGES	DEG_SCF_FBW7_1	0.1944
p.T1472A	ACH-000786	Lymphoma	CCLE	VRTPGES	DEG_SCF_FBW7_1	0.825
p.T1472A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VRTPGES	DEG_SCF_FBW7_1	0.825
p.T1476A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VRTPGES	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SCF_FBW7_1	1470:1476	VRTPGES	FBXW7	0.9736	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons