DegronMD

Uniprot ID: Q9ULT8

Source protein: E3 ubiquitin-protein ligase HECTD1

Source gene: HECTD1

Class: DEG_SCF_FBW7_1

Location: 1599:1605

E3 ligase: FBXW7

DEGRON score: 0.617

ASA_SCORE: 82.3286

COIL: 0.9046

CONS_SCORE: 0.376

DSS_SCORE: 0.5208

HELIX: 0.0319

FCONS_SCORE: 0.9178

RIG_SCORE: 0.6817

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1599F	TCGA-C5-A7UH	CESC	TCGA	LTTPGTT	DEG_SCF_FBW7_1	0.6981
p.L1599F	DO49891	CESC	ICGC	LTTPGTT	DEG_SCF_FBW7_1	0.6981
p.G1592C	TCGA-D3-A3CE	SKCM	TCGA	LTTPGTT	DEG_SCF_FBW7_1	0.1389
p.G1592C	DO37405	SKCM	ICGC	LTTPGTT	DEG_SCF_FBW7_1	0.1389
p.P1597L	TCGA-EE-A2GO	SKCM	TCGA	LTTPGTT	DEG_SCF_FBW7_1	0.2778
p.P1597L	DO37823	SKCM	ICGC	LTTPGTT	DEG_SCF_FBW7_1	0.2778
p.S1613Y	DO229459	SKCA	ICGC	LTTPGTT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SCF_FBW7_1	1599:1605	LTTPGTT	FBXW7	0.617	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons