DegronMD

Uniprot ID: Q9ULT8

Source protein: E3 ubiquitin-protein ligase HECTD1

Source gene: HECTD1

Class: DEG_SCF_FBW7_2

Location: 1797:1804

E3 ligase: FBXW7

DEGRON score: 0.9541

ASA_SCORE: 87.075

COIL: 0.8143

CONS_SCORE: 0.4442

DSS_SCORE: 0.6845

HELIX: 0.1715

FCONS_SCORE: 0.9948

RIG_SCORE: 0.6216

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1800A	TCGA-AA-3715	COAD	TCGA	PPGTPHSE	DEG_SCF_FBW7_2	0.825
p.T1800A	DO8018	COAD	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	0.825
p.E1804D	TCGA-B5-A1MR	UCEC	TCGA	PPGTPHSE	DEG_SCF_FBW7_2	0.6758
p.E1804D	DO41758	UCEC	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	0.6758
p.E1794Q	TCGA-CQ-5334	HNSC	TCGA	PPGTPHSE	DEG_SCF_FBW7_2	0.25
p.E1794Q	DO16053	HNSC	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	0.25
p.P1796Q	TCGA-D3-A2J6	SKCM	TCGA	PPGTPHSE	DEG_SCF_FBW7_2	0.3056
p.P1796Q	DO37901	SKCM	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	0.3056
p.E1810K	TCGA-EI-6917	READ	TCGA	PPGTPHSE	DEG_SCF_FBW7_2	0.1667
p.E1810K	DO222769	COCA	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	0.1667
p.E1810K	DO36881	READ	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	0.1667
p.T1791A	DO50531	BOCA	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	0.1667
p.Q1788K	DO228974	LICA	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	0.0833
p.P1797T	DO228971	LICA	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	0.7031
p.Q1789K	DO228986	LICA	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	0.1111
p.I1795L	DO47162	RECA	ICGC	PPGTPHSE	DEG_SCF_FBW7_2	0.2778
p.T1800S	SIDM01045	Endometrial Carcinoma	GDSC	PPGTPHSE	DEG_SCF_FBW7_2	0.8227
p.T1800S	ACH-000978	Endometrial/Uterine Cancer	CCLE	PPGTPHSE	DEG_SCF_FBW7_2	0.8227
p.T1800S	EN	endometrium	COSMIC	PPGTPHSE	DEG_SCF_FBW7_2	0.8227
p.P1801S	SIDM01434	Hepatocellular Carcinoma	GDSC	PPGTPHSE	DEG_SCF_FBW7_2	0.6752
p.P1801S	ACH-000316	Liver Cancer	CCLE	PPGTPHSE	DEG_SCF_FBW7_2	0.6752
p.L1805I	ACH-000458	Skin Cancer	CCLE	PPGTPHSE	DEG_SCF_FBW7_2	0.3056
p.R1788H	SNU-1040	large_intestine	COSMIC	PPGTPHSE	DEG_SCF_FBW7_2	0.0833
p.T1804S	EN	endometrium	COSMIC	PPGTPHSE	DEG_SCF_FBW7_2	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SCF_FBW7_2	1797:1804	PPGTPHSE	FBXW7	0.9541	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons