DegronMD

Uniprot ID: Q8IZD2

Source protein: Inactive histone-lysine N-methyltransferase 2E

Source gene: KMT2E

Class: DEG_SCF_FBW7_2

Location: 1488:1494

E3 ligase: FBXW7

DEGRON score: 0.8986

ASA_SCORE: 105.5857

COIL: 0.9664

CONS_SCORE: 0.3599

DSS_SCORE: 0.8598

HELIX: 0.0153

FCONS_SCORE: 1.0005

RIG_SCORE: 0.5759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1503V	TCGA-60-2698	LUSC	TCGA	VGTPQRE	DEG_SCF_FBW7_2	0.0833
p.T1490K	TCGA-AX-A3G3	UCEC	TCGA	VGTPQRE	DEG_SCF_FBW7_2	0.7306
p.F1499L	TCGA-B5-A1MR	UCEC	TCGA	VGTPQRE	DEG_SCF_FBW7_2	0.1944
p.R1493Q	TCGA-B6-A0IK	BRCA	TCGA	VGTPQRE	DEG_SCF_FBW7_2	0.6218
p.A1502T	TCGA-D1-A1NS	UCEC	TCGA	VGTPQRE	DEG_SCF_FBW7_2	0.1111
p.Q1495H	DO219771	UCEC	ICGC	VGTPQRE	DEG_SCF_FBW7_2	0.3056
p.T1488A	DO41752	UCEC	ICGC	VGTPQRE	DEG_SCF_FBW7_2	0.7139
p.S1483L	SIDM01131	Small Cell Lung Carcinoma	GDSC	VGTPQRE	DEG_SCF_FBW7_2	0.1944
p.S1483L	ACH-000355	Lung Cancer	CCLE	VGTPQRE	DEG_SCF_FBW7_2	0.1944
p.S1483L	NCI-H82	lung	COSMIC	VGTPQRE	DEG_SCF_FBW7_2	0.1944
p.H1481R	ACH-000143	Lung Cancer	CCLE	VGTPQRE	DEG_SCF_FBW7_2	0.1389
p.T1490I	ACH-001197	Lymphoma	CCLE	VGTPQRE	DEG_SCF_FBW7_2	0.7078
p.G1489E	ACH-001664	Gastric Cancer	CCLE	VGTPQRE	DEG_SCF_FBW7_2	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SCF_FBW7_2	1488:1494	VGTPQRE	FBXW7	0.8986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons