DegronMD

Uniprot ID: Q8IZD2

Source protein: Inactive histone-lysine N-methyltransferase 2E

Source gene: KMT2E

Class: DEG_SCF_FBW7_1

Location: 70:77

E3 ligase: FBXW7

DEGRON score: 0.9915

ASA_SCORE: 82.8

COIL: 0.9776

CONS_SCORE: 0.4957

DSS_SCORE: 0.666

HELIX: 0.008

FCONS_SCORE: 1.2198

RIG_SCORE: 0.5441

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y66C	TCGA-2G-AAGI	TGCT	TCGA	PPPTPPAS	DEG_SCF_FBW7_1	0.2222
p.P74L	TCGA-DY-A0XA	READ	TCGA	PPPTPPAS	DEG_SCF_FBW7_1	0.7582
p.P74L	DO37026	READ	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	0.7582
p.N87S	TCGA-E9-A5UO	BRCA	TCGA	PPPTPPAS	DEG_SCF_FBW7_1	0.0556
p.N87S	DO44105	BRCA	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	0.0556
p.N65H	TCGA-EI-6917	READ	TCGA	PPPTPPAS	DEG_SCF_FBW7_1	0.1944
p.N65H	DO36881	READ	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	0.1944
p.R69C	TCGA-H7-A76A	HNSC	TCGA	PPPTPPAS	DEG_SCF_FBW7_1	0.3056
p.R69C	DO52088	HNSC	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	0.3056
p.A76T	TCGA-HU-A4GX	STAD	TCGA	PPPTPPAS	DEG_SCF_FBW7_1	0.6028
p.A76T	DO47757	STAD	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	0.6028
p.A62V	TCGA-L5-A8NU	ESCA	TCGA	PPPTPPAS	DEG_SCF_FBW7_1	0.1111
p.Y61C	DO229383	BTCA	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	0.0833
p.VL82VF	DO222494	MELA	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	0
p.P71S	DO218855	SKCA	ICGC	PPPTPPAS	DEG_SCF_FBW7_1	0.5641
p.P72L	SIDM00217	Colorectal Carcinoma	GDSC	PPPTPPAS	DEG_SCF_FBW7_1	0.6471
p.P72L	ACH-000999	Colon/Colorectal Cancer	CCLE	PPPTPPAS	DEG_SCF_FBW7_1	0.6471
p.P72L	SNU-1040	large_intestine	COSMIC	PPPTPPAS	DEG_SCF_FBW7_1	0.6471
p.R85M	G-MEL	skin	COSMIC	PPPTPPAS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SCF_FBW7_1	70:77	PPPTPPAS	FBXW7	0.9915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons