DegronMD

Uniprot ID: Q8IZD2

Source protein: Inactive histone-lysine N-methyltransferase 2E

Source gene: KMT2E

Class: DEG_SCF_TRCP1_1

Location: 1280:1285

E3 ligase: BTRC

DEGRON score: 0.9793

ASA_SCORE: 86.3

COIL: 0.9578

CONS_SCORE: 0.3478

DSS_SCORE: 0.5605

HELIX: 0.0325

FCONS_SCORE: 1.0241

RIG_SCORE: 0.5245

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1276Q	TCGA-AG-A002	READ	TCGA	DSGGES	DEG_SCF_TRCP1_1	0.2222
p.R1276Q	TCGA-AX-A2HC	UCEC	TCGA	DSGGES	DEG_SCF_TRCP1_1	0.2222
p.R1276Q	DO41572	UCEC	ICGC	DSGGES	DEG_SCF_TRCP1_1	0.2222
p.D1278H	TCGA-AY-6196	COAD	TCGA	DSGGES	DEG_SCF_TRCP1_1	0.2778
p.D1278H	DO10300	COAD	ICGC	DSGGES	DEG_SCF_TRCP1_1	0.2778
p.T1293M	DO222973	BTCA	ICGC	DSGGES	DEG_SCF_TRCP1_1	0.1111
p.P1288A	DO52025	LUSC	ICGC	DSGGES	DEG_SCF_TRCP1_1	0.25
p.L1272F	DO222595	MELA	ICGC	DSGGES	DEG_SCF_TRCP1_1	0.1111
p.D1282G	DO228168	PBCA	ICGC	DSGGES	DEG_SCF_TRCP1_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SCF_TRCP1_1	1280:1285	DSGGES	BTRC	0.9793	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons