DegronMD

Uniprot ID: Q6ZSZ6

Source protein: Teashirt homolog 1

Source gene: TSHZ1

Class: DEG_SCF_FBW7_1

Location: 710:716

E3 ligase: FBXW7

DEGRON score: 0.991

ASA_SCORE: 92.0143

COIL: 0.9243

CONS_SCORE: 0.4792

DSS_SCORE: 0.6368

HELIX: 0.0267

FCONS_SCORE: 1.2326

RIG_SCORE: 0.6537

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P725L	TCGA-55-8514	LUAD	TCGA	VHTPNGT	DEG_SCF_FBW7_1	0.0833
p.P718L	TCGA-55-8620	LUAD	TCGA	VHTPNGT	DEG_SCF_FBW7_1	0.2778
p.D724N	TCGA-AA-3715	COAD	TCGA	VHTPNGT	DEG_SCF_FBW7_1	0.1111
p.A702T	DO218693	GACA	ICGC	VHTPNGT	DEG_SCF_FBW7_1	0.1111
p.A702V	DO22237	LGG	ICGC	VHTPNGT	DEG_SCF_FBW7_1	0.1111
p.P713L	DO229019	LICA	ICGC	VHTPNGT	DEG_SCF_FBW7_1	0.7582
p.G700W	DO26467	LUSC	ICGC	VHTPNGT	DEG_SCF_FBW7_1	0.0556
p.P700Q	DO32980	PACA	ICGC	VHTPNGT	DEG_SCF_FBW7_1	0.0556
p.E705K	SIDM00003	Melanoma	GDSC	VHTPNGT	DEG_SCF_FBW7_1	0.1944
p.E705K	ACH-002159	Skin Cancer	CCLE	VHTPNGT	DEG_SCF_FBW7_1	0.1944
p.E705K	M14	skin	COSMIC	VHTPNGT	DEG_SCF_FBW7_1	0.1944
p.V719M	22RV1	prostate	COSMIC	VHTPNGT	DEG_SCF_FBW7_1	0.25
p.V719L	BICR22	upper_aerodigestive_tract	COSMIC	VHTPNGT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZSZ6	Teashirt homolog 1	DEG_SCF_FBW7_1	710:716	VHTPNGT	FBXW7	0.991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons