DegronMD

Uniprot ID: Q6ZSZ6

Source protein: Teashirt homolog 1

Source gene: TSHZ1

Class: DEG_SCF_FBW7_1

Location: 851:856

E3 ligase: FBXW7

DEGRON score: 0.994

ASA_SCORE: 103.7167

COIL: 0.9527

CONS_SCORE: 0.3569

DSS_SCORE: 0.5735

HELIX: 0.018

FCONS_SCORE: 0.7105

RIG_SCORE: 0.6203

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T852S	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	LTPKSS	DEG_SCF_FBW7_1	0.8227
p.T852S	ACH-000757	Lung Cancer	CCLE	LTPKSS	DEG_SCF_FBW7_1	0.8227
p.T852S	A427	lung	COSMIC	LTPKSS	DEG_SCF_FBW7_1	0.8227
p.S856F	DO223732	CESC	ICGC	LTPKSS	DEG_SCF_FBW7_1	0.7982
p.Q856L	TCGA-56-8307	LUSC	TCGA	LTPKSS	DEG_SCF_FBW7_1	0.7765
p.L851Q	DO15999	HNSC	ICGC	LTPKSS	DEG_SCF_FBW7_1	0.7765
p.L855M	TCGA-BK-A13B	UCEC	TCGA	LTPKSS	DEG_SCF_FBW7_1	0.711
p.K854N	DO229037	LICA	ICGC	LTPKSS	DEG_SCF_FBW7_1	0.5806
p.P849L	TCGA-AP-A1DV	UCEC	TCGA	LTPKSS	DEG_SCF_FBW7_1	0.2778
p.N848S	TCGA-CM-6678	COAD	TCGA	LTPKSS	DEG_SCF_FBW7_1	0.25
p.N848S	DO10220	COAD	ICGC	LTPKSS	DEG_SCF_FBW7_1	0.25
p.R864W	TCGA-WS-AB45	COAD	TCGA	LTPKSS	DEG_SCF_FBW7_1	0.2222
p.R864W	DO51734	COAD	ICGC	LTPKSS	DEG_SCF_FBW7_1	0.2222
p.R864W	LS-411N	large_intestine	COSMIC	LTPKSS	DEG_SCF_FBW7_1	0.2222
p.R864Q	DO233262	GACA	ICGC	LTPKSS	DEG_SCF_FBW7_1	0.2222
p.N846S	DO230311	COCA	ICGC	LTPKSS	DEG_SCF_FBW7_1	0.1944
p.V861A	ACH-001385	Head and Neck Cancer	CCLE	LTPKSS	DEG_SCF_FBW7_1	0.1944
p.V861A	RPMI-2650	upper_aerodigestive_tract	COSMIC	LTPKSS	DEG_SCF_FBW7_1	0.1944
p.V844L	DO227944	BRCA	ICGC	LTPKSS	DEG_SCF_FBW7_1	0.1389
p.G842V	TCGA-NC-A5HJ	LUSC	TCGA	LTPKSS	DEG_SCF_FBW7_1	0.0833
p.G842V	DO219189	LUSC	ICGC	LTPKSS	DEG_SCF_FBW7_1	0.0833
p.D842N	DO231191	LUSC	ICGC	LTPKSS	DEG_SCF_FBW7_1	0.0833
p.S865F	SIDM00210	Ovarian Carcinoma	GDSC	LTPKSS	DEG_SCF_FBW7_1	0.0833
p.S865F	A2780	ovary	COSMIC	LTPKSS	DEG_SCF_FBW7_1	0.0833
p.T866I	TCGA-EB-A44P	SKCM	TCGA	LTPKSS	DEG_SCF_FBW7_1	0.0556

Showing 1 to 25 of 25 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZSZ6	Teashirt homolog 1	DEG_SCF_FBW7_1	851:856	LTPKSS	FBXW7	0.994	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons