DegronMD

Uniprot ID: P51532

Source protein: Transcription activator BRG1

Source gene: SMARCA4

Class: DEG_APCC_DBOX_1

Location: 1243:1251

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7725

ASA_SCORE: 52.9667

COIL: 0.0246

CONS_SCORE: 0.4285

DSS_SCORE: 0.5575

HELIX: 0.9724

FCONS_SCORE: 1.1195

RIG_SCORE: 0.7781

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1241Q	TCGA-24-2261	OV	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.2778
p.H1241Q	DO28551	OV	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.2778
p.E1242K	TCGA-43-5670	LUSC	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.3056
p.E1242K	DO26434	LUSC	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.3056
p.Q1248H	TCGA-55-8089	LUAD	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.647
p.Q1248H	DO23690	LUAD	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.647
p.R1243Q	TCGA-AA-3527	COAD	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.6218
p.R1243Q	DO9090	COAD	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.6218
p.R1244P	TCGA-B9-5156	KIRP	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.7512
p.R1244P	DO20774	KIRP	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7512
p.E1254D	TCGA-BG-A220	UCEC	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.25
p.E1254D	DO41784	UCEC	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.25
p.R1243W	TCGA-BP-4964	KIRC	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1243W	TCGA-BS-A0V4	UCEC	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1243W	TCGA-IC-A6RF	ESCA	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1243W	DO233737	GACA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1243W	DO16263	KIRC	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1243W	DO27795	MALY	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1243W	DO228368	MALY	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1243W	DO33704	PACA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1243W	DO35442	PACA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1243W	DO228138	PBCA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1243W	DO227845	PBCA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1243W	DO42969	UCEC	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.H1261Y	TCGA-CK-4951	COAD	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.0556
p.H1261Y	DO10582	COAD	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.0556
p.F1234L	TCGA-DU-7018	LGG	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.0833
p.F1234L	DO22223	LGG	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.0833
p.F1234L	DO222402	MELA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.0833
p.R1244G	TCGA-MP-A4SY	LUAD	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.7568
p.R1244G	DO45398	LUAD	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7568
p.M1233T	DO234417	ESAD	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.0556
p.K1237E	DO233804	GACA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.6111
p.S1239P	DO228419	MALY	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.2222
p.H1253Y	SIDM02036	Esophageal Carcinoma	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	0.2778
p.R1244H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	0.8244
p.R1244H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	0.8244
p.R1244H	ACH-000995	Leukemia	CCLE	RRAFLQAIL	DEG_APCC_DBOX_1	0.8244
p.R1244H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	0.8244
p.Q1248R	SIDM00889	Cervical Carcinoma	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	0.6218
p.Q1248R	ACH-001333	Cervical Cancer	CCLE	RRAFLQAIL	DEG_APCC_DBOX_1	0.6218
p.Q1248R	C-33-A	cervix	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	0.6218
p.D1235Y	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	0.1111
p.D1235Y	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	0.1111
p.D1235Y	ACH-000823	Esophageal Cancer	CCLE	RRAFLQAIL	DEG_APCC_DBOX_1	0.1111
p.D1235Y	ACH-000945	Lung Cancer	CCLE	RRAFLQAIL	DEG_APCC_DBOX_1	0.1111
p.D1235Y	NCI-H650	lung	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	0.1111
p.D1235Y	KYSE-140	oesophagus	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	0.1111
p.R1244C	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	0.8301
p.M1233I	SIDM00516	Melanoma	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	0.0556
p.M1233I	ACH-002166	Skin Cancer	CCLE	RRAFLQAIL	DEG_APCC_DBOX_1	0.0556
p.M1233I	MZ7-mel	skin	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	0.0556
p.A1250V	SNU-C2B	large_intestine	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	0.6936
p.R1256C	SUP-B8	haematopoietic_and_lymphoid_tissue	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	0.1944
p.R1256H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	0.1944

Drug responses associated with SMARCA4 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.E623* (No)	GDSC	PFI-3	40.5518
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.E623* (No)	GDSC	PFI3	132.47
SIDM01177	UNCLASSIFIED\|B_cell_leukemia	p.R1192C (No)	GDSC	PFI-3	147.8763
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G1232D (Yes)	GDSC	PFI-3	130.104
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M272fs*31 (No)	GDSC	PFI-3	79.4353
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M272fs*31 (No)	GDSC	PFI3	351.72
SIDM00210	UNCLASSIFIED\|ovary	p.T910M (No)	GDSC	PFI-3	100.8094
SIDM00210	UNCLASSIFIED\|ovary	p.T910M (No)	GDSC	PFI3	162.15
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.P270fs*16 (No)	GDSC	PFI-3	141.7397
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.P270fs*16 (No)	GDSC	PFI3	153.83
SIDM00214	COREAD\|large_intestine	p.P109fs*194 (No)	GDSC	PFI-3	124.0354
SIDM00214	COREAD\|large_intestine	p.P109fs*194 (No)	GDSC	PFI3	133.63
SIDM00932	KIRC\|kidney	p.G1232S (Yes)	GDSC	PFI-3	124.4636
SIDM00932	KIRC\|kidney	p.G1232S (Yes)	GDSC	PFI3	250.43
SIDM00781	COREAD\|large_intestine	p.A1186V (No)	GDSC	PFI3	688.48
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.E514* (No)	GDSC	PFI-3	278.7279
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.E514* (No)	GDSC	PFI3	1060.7
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.A1245fs*13 (Yes)	GDSC	PFI-3	73.4868
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.A1245fs*13 (Yes)	GDSC	PFI3	118.96
SIDM00145	ALL\|lymphoblastic_leukemia	p.P109fs*194 (No)	GDSC	PFI-3	37.5832
SIDM00145	ALL\|lymphoblastic_leukemia	p.P109fs*194 (No)	GDSC	PFI3	137.96
SIDM00814	ACC\|adrenal_gland	p.Q164* (No)	GDSC	PFI-3	48.5692
SIDM00814	ACC\|adrenal_gland	p.Q164* (No)	GDSC	PFI3	22.895
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.K635fs*9 (No)	GDSC	PFI-3	60.7946
SIDM00694	UNCLASSIFIED\|digestive_system_other	p.K635fs*9 (No)	GDSC	PFI3	69.546
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.L1085fs*32 (No)	GDSC	PFI-3	301.0987
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.L1085fs*32 (No)	GDSC	PFI3	1300.7
SIDM00112	KIRC\|kidney	p.R885L (No)	GDSC	PFI-3	38.2464
SIDM00946	ALL\|T_cell_leukemia	p.Q165* (No)	GDSC	PFI-3	68.7687
SIDM00946	ALL\|T_cell_leukemia	p.Q165* (No)	GDSC	PFI3	72.351
SIDM00783	COREAD\|large_intestine	p.S122fs*7 (No)	GDSC	PFI3	118.53
SIDM01170	OV\|ovary	p.L639fs*7 (No)	GDSC	PFI-3	41.6612
SIDM01170	OV\|ovary	p.L639fs*7 (No)	GDSC	PFI3	168.76
SIDM00933	BRCA\|breast	p.R885H (No)	GDSC	PFI-3	81.8615
SIDM00933	BRCA\|breast	p.R885H (No)	GDSC	PFI3	156.34
SIDM00216	COREAD\|large_intestine	p.R966W (No)	GDSC	PFI3	158.44
SIDM00282	COREAD\|large_intestine	p.G1232D (Yes)	GDSC	PFI3	216.01
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.K934* (No)	GDSC	PFI-3	80.4494
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.K934* (No)	GDSC	PFI3	399.93
SIDM00474	OV\|ovary	p.Q1185* (No)	GDSC	PFI-3	96.5349
SIDM00238	OV\|ovary	p.P109fs*194 (No)	GDSC	PFI-3	165.7618
SIDM00238	OV\|ovary	p.P109fs*194 (No)	GDSC	PFI3	373.9
SIDM00047	LUAD\|lung_NSCLC_adenocarcinoma	p.E608* (No)	GDSC	PFI-3	109.6087
SIDM00047	LUAD\|lung_NSCLC_adenocarcinoma	p.E608* (No)	GDSC	PFI3	231.63
SIDM00224	MESO\|mesothelioma	p.E449fs*46 (No)	GDSC	PFI3	238.21
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.S828fs*3 (No)	GDSC	PFI-3	158.9008
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.S828fs*3 (No)	GDSC	PFI3	158.38
SIDM00748	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1310* (No)	GDSC	PFI-3	57.8215
SIDM00748	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1310* (No)	GDSC	PFI3	38.556
SIDM00114	MESO\|mesothelioma	p.E1056* (No)	GDSC	PFI-3	256.9894
SIDM00114	MESO\|mesothelioma	p.E1056* (No)	GDSC	PFI3	819.54
SIDM00980	STAD\|stomach	p.E952fs*5 (No)	GDSC	PFI-3	60.4445
SIDM00980	STAD\|stomach	p.E952fs*5 (No)	GDSC	PFI3	257.17
SIDM00119	LUAD\|lung_NSCLC_adenocarcinoma	p.Q418* (No)	GDSC	PFI-3	53.6996
SIDM00119	LUAD\|lung_NSCLC_adenocarcinoma	p.Q418* (No)	GDSC	PFI3	314.4
SIDM00865	SCLC\|lung_small_cell_carcinoma	p.E1310* (No)	GDSC	PFI-3	115.0371
SIDM00865	SCLC\|lung_small_cell_carcinoma	p.E1310* (No)	GDSC	PFI3	126.66
SIDM00903	LUAD\|lung_NSCLC_adenocarcinoma	p.Q729fs*4 (No)	GDSC	PFI-3	68.573
SIDM00903	LUAD\|lung_NSCLC_adenocarcinoma	p.Q729fs*4 (No)	GDSC	PFI3	385.45
SIDM01070	UNCLASSIFIED\|lung_NSCLC_not_specified	p.W1178* (No)	GDSC	PFI-3	131.8981
SIDM01070	UNCLASSIFIED\|lung_NSCLC_not_specified	p.W1178* (No)	GDSC	PFI3	173.69
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R885L (No)	GDSC	PFI-3	204.3988
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R885L (No)	GDSC	PFI3	209
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.E463* (No)	GDSC	PFI-3	107.5337
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.E463* (No)	GDSC	PFI3	220.13
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.E821K (No)	GDSC	PFI3	65.695
SIDM00080	SKCM\|melanoma	p.Q1053fs*53 (No)	GDSC	PFI-3	157.1925
SIDM00080	SKCM\|melanoma	p.Q1053fs*53 (No)	GDSC	PFI3	255.28
SIDM00290	STAD\|stomach	p.K689delK (No)	GDSC	PFI-3	47.5579
SIDM00290	STAD\|stomach	p.K689delK (No)	GDSC	PFI3	129.9
SIDM00509	SCLC\|lung_small_cell_carcinoma	p.A826S (No)	GDSC	PFI3	41.411
SIDM00889	CESC\|cervix	p.N772_L773insN (No)	GDSC	PFI-3	59.1782
SIDM00889	CESC\|cervix	p.N772_L773insN (No)	GDSC	PFI3	199.94
SIDM00327	UNCLASSIFIED\|Hodgkin_lymphoma	p.L921F (No)	GDSC	PFI-3	77.1904
SIDM00327	UNCLASSIFIED\|Hodgkin_lymphoma	p.L921F (No)	GDSC	PFI3	59.735
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A321T (No)	GDSC	PFI-3	50.9052
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A321T (No)	GDSC	PFI3	22.92
SIDM01031	ESCA\|oesophagus	p.N944K (No)	GDSC	PFI-3	96.7477
SIDM00358	STAD\|stomach	p.Q915H (No)	GDSC	PFI-3	125.1931
SIDM00358	STAD\|stomach	p.Q915H (No)	GDSC	PFI3	292.35
SIDM01029	ESCA\|oesophagus	p.T494R (No)	GDSC	PFI-3	44.7951
SIDM01029	ESCA\|oesophagus	p.T494R (No)	GDSC	PFI3	174.59
SIDM00572	STAD\|stomach	p.A136V (No)	GDSC	PFI-3	111.6851
SIDM00572	STAD\|stomach	p.A136V (No)	GDSC	PFI3	159.51
SIDM00210	UNCLASSIFIED\|ovary	p.R1356W (No)	GDSC	PFI-3	100.8094
SIDM00210	UNCLASSIFIED\|ovary	p.R1356W (No)	GDSC	PFI3	162.15
SIDM01086	ALL\|leukemia	p.R167W (No)	GDSC	PFI-3	42.4835
SIDM01086	ALL\|leukemia	p.R167W (No)	GDSC	PFI3	91.199
SIDM00607	LGG\|glioma	p.P285T (No)	GDSC	PFI-3	150.6466
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.E1431* (No)	GDSC	PFI-3	158.705
SIDM00151	OV\|ovary	p.D1448N (No)	GDSC	PFI-3	224.4307
SIDM00151	OV\|ovary	p.D1448N (No)	GDSC	PFI3	51.787
SIDM01032	ESCA\|oesophagus	p.D1235Y (Yes)	GDSC	PFI3	46.059
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.D543N (No)	GDSC	PFI-3	32.4513
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.D543N (No)	GDSC	PFI3	83.143
SIDM00661	DLBC\|B_cell_lymphoma	p.C891W (No)	GDSC	PFI-3	58.9549
SIDM00683	PRAD\|prostate	p.R726H (No)	GDSC	PFI-3	149.7318
SIDM00683	PRAD\|prostate	p.R726H (No)	GDSC	PFI3	251.37
SIDM00901	UCEC\|endometrium	p.P1488L (No)	GDSC	PFI-3	25.0086
SIDM00901	UCEC\|endometrium	p.P1488L (No)	GDSC	PFI3	103.27
SIDM00745	LUAD\|lung_NSCLC_adenocarcinoma	p.N1164Y (No)	GDSC	PFI-3	9.3231
SIDM00745	LUAD\|lung_NSCLC_adenocarcinoma	p.N1164Y (No)	GDSC	PFI3	1493.2
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.K1598N (No)	GDSC	PFI-3	106.7362
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.K1598N (No)	GDSC	PFI3	94.029
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.E1599* (No)	GDSC	PFI-3	106.7362
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.E1599* (No)	GDSC	PFI3	94.029
SIDM01007	ALL\|lymphoblastic_leukemia	p.E590K (No)	GDSC	PFI-3	71.009
SIDM01007	ALL\|lymphoblastic_leukemia	p.E590K (No)	GDSC	PFI3	44.829
SIDM01007	ALL\|lymphoblastic_leukemia	p.S655P (No)	GDSC	PFI-3	71.009
SIDM01007	ALL\|lymphoblastic_leukemia	p.S655P (No)	GDSC	PFI3	44.829
SIDM00781	COREAD\|large_intestine	p.R1511H (No)	GDSC	PFI3	688.48
SIDM00677	COREAD\|large_intestine	p.R973W (No)	GDSC	PFI-3	144.385
SIDM00677	COREAD\|large_intestine	p.R973W (No)	GDSC	PFI3	257.7
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.G1159W (No)	GDSC	PFI-3	87.8593
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.G1159W (No)	GDSC	PFI3	149.37
SIDM00214	COREAD\|large_intestine	p.R466C (No)	GDSC	PFI-3	124.0354
SIDM00214	COREAD\|large_intestine	p.R466C (No)	GDSC	PFI3	133.63
SIDM00214	COREAD\|large_intestine	p.Y507H (No)	GDSC	PFI-3	124.0354
SIDM00214	COREAD\|large_intestine	p.Y507H (No)	GDSC	PFI3	133.63
SIDM00214	COREAD\|large_intestine	p.M1109V (No)	GDSC	PFI-3	124.0354
SIDM00214	COREAD\|large_intestine	p.M1109V (No)	GDSC	PFI3	133.63
SIDM00176	UNCLASSIFIED\|chondrosarcoma	p.V1377G (No)	GDSC	PFI-3	102.8319
SIDM00176	UNCLASSIFIED\|chondrosarcoma	p.V1377G (No)	GDSC	PFI3	90.816
SIDM01088	UNCLASSIFIED\|endometrium	p.Y120S (No)	GDSC	PFI-3	112.7272
SIDM01088	UNCLASSIFIED\|endometrium	p.Y120S (No)	GDSC	PFI3	142.23
SIDM01088	UNCLASSIFIED\|endometrium	p.R167Q (No)	GDSC	PFI-3	112.7272
SIDM01088	UNCLASSIFIED\|endometrium	p.R167Q (No)	GDSC	PFI3	142.23
SIDM01088	UNCLASSIFIED\|endometrium	p.E1609G (No)	GDSC	PFI-3	112.7272
SIDM01088	UNCLASSIFIED\|endometrium	p.E1609G (No)	GDSC	PFI3	142.23
SIDM00516	SKCM\|melanoma	p.M1233I (Yes)	GDSC	PFI-3	96.5741
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.K1365delK (No)	GDSC	PFI-3	73.8625
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.K1365delK (No)	GDSC	PFI3	3550.9
SIDM00124	KIRC\|kidney	p.A923P (No)	GDSC	PFI-3	23.1962
SIDM00124	KIRC\|kidney	p.A923P (No)	GDSC	PFI3	422.63
SIDM00151	OV\|ovary	p.E1212delE (No)	GDSC	PFI-3	224.4307
SIDM00151	OV\|ovary	p.E1212delE (No)	GDSC	PFI3	51.787
SIDM01029	ESCA\|oesophagus	p.M76fs*18 (No)	GDSC	PFI-3	44.7951
SIDM01029	ESCA\|oesophagus	p.M76fs*18 (No)	GDSC	PFI3	174.59
SIDM01045	UCEC\|endometrium	p.G603D (No)	GDSC	PFI-3	219.324
SIDM01045	UCEC\|endometrium	p.G603D (No)	GDSC	PFI3	432.37
SIDM01028	ESCA\|oesophagus	p.V1207I (No)	GDSC	PFI3	430.24
SIDM00946	ALL\|T_cell_leukemia	p.S1441T (No)	GDSC	PFI-3	68.7687
SIDM00946	ALL\|T_cell_leukemia	p.S1441T (No)	GDSC	PFI3	72.351
SIDM01055	LGG\|glioma	p.E1531* (No)	GDSC	PFI-3	108.2518
SIDM01055	LGG\|glioma	p.E1531* (No)	GDSC	PFI3	61.257
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.N774K (No)	GDSC	PFI-3	159.3701
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.N774K (No)	GDSC	PFI3	677.83
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.D1450Y (No)	GDSC	PFI-3	123.2675
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.D1450Y (No)	GDSC	PFI3	349.12
SIDM00999	BLCA\|bladder	p.R1203H (No)	GDSC	PFI-3	80.4018
SIDM00999	BLCA\|bladder	p.R1203H (No)	GDSC	PFI3	139.3
SIDM00999	BLCA\|bladder	p.R1477W (No)	GDSC	PFI-3	80.4018
SIDM00999	BLCA\|bladder	p.R1477W (No)	GDSC	PFI3	139.3
SIDM00217	COREAD\|large_intestine	p.G256R (No)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.G256R (No)	GDSC	PFI3	324.58
SIDM00217	COREAD\|large_intestine	p.A733V (No)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.A733V (No)	GDSC	PFI3	324.58
SIDM00217	COREAD\|large_intestine	p.A778V (No)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.A778V (No)	GDSC	PFI3	324.58
SIDM00217	COREAD\|large_intestine	p.R905H (No)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.R905H (No)	GDSC	PFI3	324.58
SIDM00217	COREAD\|large_intestine	p.R1547H (No)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.R1547H (No)	GDSC	PFI3	324.58
SIDM00094	KIRC\|kidney	p.G1159V (No)	GDSC	PFI-3	52.1218
SIDM00094	KIRC\|kidney	p.G1159V (No)	GDSC	PFI3	233.28
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.R1461H (No)	GDSC	PFI-3	60.1801
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.R1461H (No)	GDSC	PFI3	191.92
SIDM00889	CESC\|cervix	p.M527T (No)	GDSC	PFI-3	59.1782
SIDM00889	CESC\|cervix	p.M527T (No)	GDSC	PFI3	199.94
SIDM00889	CESC\|cervix	p.Q1248R (Yes)	GDSC	PFI-3	59.1782
SIDM00889	CESC\|cervix	p.Q1248R (Yes)	GDSC	PFI3	199.94
SIDM00889	CESC\|cervix	p.Q1569* (No)	GDSC	PFI-3	59.1782
SIDM00889	CESC\|cervix	p.Q1569* (No)	GDSC	PFI3	199.94
SIDM00216	COREAD\|large_intestine	p.A379T (No)	GDSC	PFI3	158.44
SIDM00216	COREAD\|large_intestine	p.A1500G (No)	GDSC	PFI3	158.44
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.R1135W (No)	GDSC	PFI-3	58.3105
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.R1135W (No)	GDSC	PFI3	39.444
SIDM00637	DLBC\|B_cell_lymphoma	p.E1255_E1258delEQDE (Yes)	GDSC	PFI-3	17.5796
SIDM00282	COREAD\|large_intestine	p.R89H (No)	GDSC	PFI3	216.01
SIDM00282	COREAD\|large_intestine	p.E1364A (No)	GDSC	PFI3	216.01
SIDM01088	UNCLASSIFIED\|endometrium	p.K887delK (No)	GDSC	PFI-3	112.7272
SIDM01088	UNCLASSIFIED\|endometrium	p.K887delK (No)	GDSC	PFI3	142.23
SIDM00474	OV\|ovary	p.E780K (No)	GDSC	PFI-3	96.5349
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.K689delK (No)	GDSC	PFI-3	98.9081
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.K689delK (No)	GDSC	PFI3	668.65
SIDM00996	THCA\|thyroid	p.D694E (No)	GDSC	PFI3	142.06
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.D1450E (No)	GDSC	PFI-3	76.7005
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.D1450E (No)	GDSC	PFI3	77.32
SIDM00905	CESC\|cervix	p.R973Q (No)	GDSC	PFI3	196.29
SIDM00322	ESCA\|oesophagus	p.N1486H (No)	GDSC	PFI-3	104.3713
SIDM00458	LAML\|acute_myeloid_leukaemia	p.N926I (No)	GDSC	PFI-3	32.496
SIDM00458	LAML\|acute_myeloid_leukaemia	p.N926I (No)	GDSC	PFI3	95.391
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.G1162C (No)	GDSC	PFI-3	98.506
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.G1162C (No)	GDSC	PFI3	144.97
SIDM00534	COREAD\|large_intestine	p.N173H (No)	GDSC	PFI3	214.69
SIDM00487	COREAD\|large_intestine	p.M27I (No)	GDSC	PFI-3	146.2714
SIDM00487	COREAD\|large_intestine	p.M27I (No)	GDSC	PFI3	177.12
SIDM00487	COREAD\|large_intestine	p.V420A (No)	GDSC	PFI-3	146.2714
SIDM00487	COREAD\|large_intestine	p.V420A (No)	GDSC	PFI3	177.12
SIDM00487	COREAD\|large_intestine	p.P647L (No)	GDSC	PFI-3	146.2714
SIDM00487	COREAD\|large_intestine	p.P647L (No)	GDSC	PFI3	177.12
SIDM00487	COREAD\|large_intestine	p.R1477W (No)	GDSC	PFI-3	146.2714
SIDM00487	COREAD\|large_intestine	p.R1477W (No)	GDSC	PFI3	177.12
SIDM01044	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V268M (No)	GDSC	PFI-3	69.8564
SIDM01044	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V268M (No)	GDSC	PFI3	144.32
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E861K (No)	GDSC	PFI-3	137.2164
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.G44E (No)	GDSC	PFI-3	42.0277
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.G44E (No)	GDSC	PFI3	179.69
SIDM01110	LIHC\|liver	p.E1614* (No)	GDSC	PFI-3	56.8019
SIDM01110	LIHC\|liver	p.E1614* (No)	GDSC	PFI3	170.05
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.E1481* (No)	GDSC	PFI-3	128.1114
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.E1481* (No)	GDSC	PFI3	357.61
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L1138P (No)	GDSC	PFI-3	87.363
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L1138P (No)	GDSC	PFI3	142.58
SIDM00373	UCEC\|endometrium	p.A322T (No)	GDSC	PFI-3	71.0053
SIDM00373	UCEC\|endometrium	p.A322T (No)	GDSC	PFI3	112.14
SIDM00364	ALL\|lymphoblastic_leukemia	p.A161T (No)	GDSC	PFI-3	40.2331
SIDM00364	ALL\|lymphoblastic_leukemia	p.A161T (No)	GDSC	PFI3	54.548
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.D1235Y (Yes)	GDSC	PFI-3	204.3988
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.D1235Y (Yes)	GDSC	PFI3	209
SIDM00537	COREAD\|large_intestine	p.I879V (No)	GDSC	PFI3	128.74
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.D881G (No)	GDSC	PFI-3	56.4075
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.D881G (No)	GDSC	PFI3	43.984
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.G784E (No)	GDSC	PFI-3	193.9323
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.G784E (No)	GDSC	PFI3	96.178
SIDM00043	HNSC\|head_and_neck	p.P1487S (No)	GDSC	PFI-3	47.4218
SIDM00043	HNSC\|head_and_neck	p.P1487S (No)	GDSC	PFI3	226.44
SIDM00193	COREAD\|large_intestine	p.E523K (No)	GDSC	PFI-3	219.9618
SIDM00193	COREAD\|large_intestine	p.E523K (No)	GDSC	PFI3	121.3
SIDM01098	NB\|neuroblastoma	p.R973W (No)	GDSC	PFI-3	99.4964

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51531	Probable global transcription activator SNF2L2	DEG_APCC_DBOX_1	1213:1221	RRAFLQAIL	APC,CDC20,FZR1	0.681	More...
P51532	Transcription activator BRG1	DEG_APCC_DBOX_1	1243:1251	RRAFLQAIL	APC,CDC20,FZR1	0.7725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRAFLQAIL

Degron related mutations and impact score

Drug responses associated with SMARCA4 mutations

All proteins holding degron of RRAFLQAIL