DegronMD

Uniprot ID: P51531

Source protein: Probable global transcription activator SNF2L2

Source gene: SMARCA2

Class: DEG_APCC_DBOX_1

Location: 1213:1221

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.681

ASA_SCORE: 56.4111

COIL: 0.0383

CONS_SCORE: 0.4802

DSS_SCORE: 0.5553

HELIX: 0.9549

FCONS_SCORE: 1.1114

RIG_SCORE: 0.743

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1218R	TCGA-AA-A02R	COAD	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.6218
p.N1227S	TCGA-B6-A0RH	BRCA	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.1667
p.N1227S	DO2162	BRCA	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.1667
p.D1205N	TCGA-BG-A222	UCEC	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.1111
p.D1205N	DO42977	UCEC	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.1111
p.E1228D	TCGA-EE-A3AG	SKCM	TCGA	RRAFLQAIL	DEG_APCC_DBOX_1	0.1389
p.E1228D	DO37471	SKCM	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.1389
p.R1213W	DO52653	MALY	ICGC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1213W	SIDM00999	Bladder Carcinoma	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1213W	SIDM00217	Colorectal Carcinoma	GDSC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1213W	ACH-000973	Bladder Cancer	CCLE	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1213W	ACH-000999	Colon/Colorectal Cancer	CCLE	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1213W	SNU-1040	large_intestine	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.R1213W	639-V	urinary_tract	COSMIC	RRAFLQAIL	DEG_APCC_DBOX_1	0.7523
p.E1224Q	ACH-000975	Lung Cancer	CCLE	RRAFLQAIL	DEG_APCC_DBOX_1	0.25

Drug responses associated with SMARCA2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P312L (No)	GDSC	PFI-3	204.3988
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P312L (No)	GDSC	PFI3	209
SIDM01228	SKCM\|melanoma	p.N1113S (No)	GDSC	PFI-3	75.0714
SIDM01228	SKCM\|melanoma	p.N1113S (No)	GDSC	PFI3	157.47
SIDM00240	CESC\|cervix	p.D634N (No)	GDSC	PFI-3	142.7594
SIDM00772	BRCA\|breast	p.R1246Q (No)	GDSC	PFI-3	218.7512
SIDM00588	HNSC\|head_and_neck	p.E362K (No)	GDSC	PFI-3	49.5615
SIDM00588	HNSC\|head_and_neck	p.E362K (No)	GDSC	PFI3	213.27
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.P153L (No)	GDSC	PFI-3	43.4812
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.P153L (No)	GDSC	PFI3	89.798
SIDM00151	OV\|ovary	p.P101Q (No)	GDSC	PFI-3	224.4307
SIDM00151	OV\|ovary	p.P101Q (No)	GDSC	PFI3	51.787
SIDM00453	PAAD\|pancreas	p.L946S (No)	GDSC	PFI-3	114.4928
SIDM00453	PAAD\|pancreas	p.L946S (No)	GDSC	PFI3	209.15
SIDM00818	KIRC\|kidney	p.G1164W (No)	GDSC	PFI-3	121.0408
SIDM01007	ALL\|lymphoblastic_leukemia	p.A470T (No)	GDSC	PFI-3	71.009
SIDM01007	ALL\|lymphoblastic_leukemia	p.A470T (No)	GDSC	PFI3	44.829
SIDM00781	COREAD\|large_intestine	p.R1162H (No)	GDSC	PFI3	688.48
SIDM00142	UCEC\|endometrium	p.Q865H (No)	GDSC	PFI-3	144.9854
SIDM00142	UCEC\|endometrium	p.Q865H (No)	GDSC	PFI3	269.25
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R525C (No)	GDSC	PFI-3	82.2867
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R525C (No)	GDSC	PFI3	71.194
SIDM00498	COREAD\|large_intestine	p.Y689H (No)	GDSC	PFI-3	163.8794
SIDM00498	COREAD\|large_intestine	p.Y689H (No)	GDSC	PFI3	487.06
SIDM01197	COREAD\|large_intestine	p.A459S (No)	GDSC	PFI-3	496.5082
SIDM01197	COREAD\|large_intestine	p.A459S (No)	GDSC	PFI3	665.17
SIDM01045	UCEC\|endometrium	p.V1194M (No)	GDSC	PFI-3	219.324
SIDM01045	UCEC\|endometrium	p.V1194M (No)	GDSC	PFI3	432.37
SIDM00864	CESC\|cervix	p.I678V (No)	GDSC	PFI3	222.76
SIDM00425	OV\|ovary	p.R1162C (No)	GDSC	PFI-3	81.0505
SIDM00425	OV\|ovary	p.R1162C (No)	GDSC	PFI3	392.62
SIDM00999	BLCA\|bladder	p.R1213W (Yes)	GDSC	PFI-3	80.4018
SIDM00999	BLCA\|bladder	p.R1213W (Yes)	GDSC	PFI3	139.3
SIDM00507	UNCLASSIFIED\|lung_other	p.R504L (No)	GDSC	PFI-3	82.7248
SIDM00217	COREAD\|large_intestine	p.R100Q (No)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.R100Q (No)	GDSC	PFI3	324.58
SIDM00217	COREAD\|large_intestine	p.V177A (No)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.V177A (No)	GDSC	PFI3	324.58
SIDM00217	COREAD\|large_intestine	p.R420C (No)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.R420C (No)	GDSC	PFI3	324.58
SIDM00217	COREAD\|large_intestine	p.L1096F (No)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.L1096F (No)	GDSC	PFI3	324.58
SIDM00217	COREAD\|large_intestine	p.R1213W (Yes)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.R1213W (Yes)	GDSC	PFI3	324.58
SIDM00217	COREAD\|large_intestine	p.R1421* (No)	GDSC	PFI-3	211.4446
SIDM00217	COREAD\|large_intestine	p.R1421* (No)	GDSC	PFI3	324.58
SIDM00140	SKCM\|melanoma	p.H466Y (No)	GDSC	PFI-3	164.7422
SIDM00140	SKCM\|melanoma	p.H466Y (No)	GDSC	PFI3	217.86
SIDM00898	BRCA\|breast	p.R424K (No)	GDSC	PFI3	217.08
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.G92V (No)	GDSC	PFI-3	69.1346
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.G92V (No)	GDSC	PFI3	66.771
SIDM00477	ESCA\|oesophagus	p.Q520E (No)	GDSC	PFI-3	155.79
SIDM00477	ESCA\|oesophagus	p.Q520E (No)	GDSC	PFI3	321.12
SIDM00282	COREAD\|large_intestine	p.R875G (No)	GDSC	PFI3	216.01
SIDM00282	COREAD\|large_intestine	p.R1311C (No)	GDSC	PFI3	216.01
SIDM00660	COREAD\|large_intestine	p.A681T (No)	GDSC	PFI-3	162.7185
SIDM00660	COREAD\|large_intestine	p.A681T (No)	GDSC	PFI3	266.95
SIDM00783	COREAD\|large_intestine	p.R855Q (No)	GDSC	PFI3	118.53
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.R811L (No)	GDSC	PFI-3	80.127
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S1408C (No)	GDSC	PFI-3	76.7005
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S1408C (No)	GDSC	PFI3	77.32
SIDM00819	KIRC\|kidney	p.K1533I (No)	GDSC	PFI-3	155.3515
SIDM00789	COREAD\|large_intestine	p.A29V (No)	GDSC	PFI3	211.15
SIDM00789	COREAD\|large_intestine	p.E1578G (No)	GDSC	PFI3	211.15
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.L1108S (No)	GDSC	PFI-3	347.6687
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.L1108S (No)	GDSC	PFI3	879.62
SIDM00487	COREAD\|large_intestine	p.R979H (No)	GDSC	PFI-3	146.2714
SIDM00487	COREAD\|large_intestine	p.R979H (No)	GDSC	PFI3	177.12
SIDM00867	GBM\|glioma	p.P664S (No)	GDSC	PFI3	2491.8
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.W892L (No)	GDSC	PFI-3	73.4868
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.W892L (No)	GDSC	PFI3	118.96
SIDM00120	PRAD\|prostate	p.P808L (No)	GDSC	PFI-3	46.6515
SIDM00120	PRAD\|prostate	p.P808L (No)	GDSC	PFI3	309.88
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.P58L (No)	GDSC	PFI-3	65.6013
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.P58L (No)	GDSC	PFI3	200.48
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.K1191R (No)	GDSC	PFI-3	65.6013
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.K1191R (No)	GDSC	PFI3	200.48
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S26N (No)	GDSC	PFI-3	65.6013
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.S26N (No)	GDSC	PFI3	200.48
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.W271L (No)	GDSC	PFI-3	128.1114
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.W271L (No)	GDSC	PFI3	357.61
SIDM00373	UCEC\|endometrium	p.R1349* (No)	GDSC	PFI-3	71.0053
SIDM00373	UCEC\|endometrium	p.R1349* (No)	GDSC	PFI3	112.14
SIDM00465	OV\|ovary	p.Q758H (No)	GDSC	PFI-3	161.6722
SIDM00465	OV\|ovary	p.Q758H (No)	GDSC	PFI3	624.67
SIDM01182	BLCA\|bladder	p.Q1074H (No)	GDSC	PFI-3	88.1653
SIDM00511	SCLC\|lung_small_cell_carcinoma	p.E1212* (Yes)	GDSC	PFI-3	82.5248
SIDM00746	LUAD\|lung_NSCLC_adenocarcinoma	p.Q549E (No)	GDSC	PFI-3	205.1719
SIDM01169	OV\|ovary	p.Q253delQ (No)	GDSC	PFI-3	105.0083
SIDM01169	OV\|ovary	p.Q253delQ (No)	GDSC	PFI3	257.16
SIDM00537	COREAD\|large_intestine	p.L782P (No)	GDSC	PFI3	128.74
SIDM00537	COREAD\|large_intestine	p.L1343I (No)	GDSC	PFI3	128.74
SIDM01246	NB\|neuroblastoma	p.R559K (No)	GDSC	PFI-3	41.9348
SIDM00878	BRCA\|breast	p.R696G (No)	GDSC	PFI-3	92.8918
SIDM00878	BRCA\|breast	p.R696G (No)	GDSC	PFI3	140.37
SIDM00356	LUAD\|lung_NSCLC_adenocarcinoma	p.G1202C (Yes)	GDSC	PFI-3	150.2792
SIDM00356	LUAD\|lung_NSCLC_adenocarcinoma	p.G1202C (Yes)	GDSC	PFI3	189.79

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51531	Probable global transcription activator SNF2L2	DEG_APCC_DBOX_1	1213:1221	RRAFLQAIL	APC,CDC20,FZR1	0.681	More...
P51532	Transcription activator BRG1	DEG_APCC_DBOX_1	1243:1251	RRAFLQAIL	APC,CDC20,FZR1	0.7725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRAFLQAIL

Degron related mutations and impact score

Drug responses associated with SMARCA2 mutations

All proteins holding degron of RRAFLQAIL