DegronMD

Uniprot ID: P08235

Source protein: Mineralocorticoid receptor

Source gene: NR3C2

Class: DEG_SCF_FBW7_1

Location: 157:163

E3 ligase: FBXW7

DEGRON score: 0.8321

ASA_SCORE: 84.2429

COIL: 0.832

CONS_SCORE: 0.526

DSS_SCORE: 0.3788

HELIX: 0.103

FCONS_SCORE: 0.982

RIG_SCORE: 0.7854

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R162I	TCGA-AX-A2HC	UCEC	TCGA	VNTPLRS	DEG_SCF_FBW7_1	0.6991
p.R162I	DO41572	UCEC	ICGC	VNTPLRS	DEG_SCF_FBW7_1	0.6991
p.V172M	TCGA-CD-A4MI	STAD	TCGA	VNTPLRS	DEG_SCF_FBW7_1	0.0833
p.V172M	DO47717	STAD	ICGC	VNTPLRS	DEG_SCF_FBW7_1	0.0833
p.P160L	TCGA-CG-4306	STAD	TCGA	VNTPLRS	DEG_SCF_FBW7_1	0.7582
p.P160L	DO38567	STAD	ICGC	VNTPLRS	DEG_SCF_FBW7_1	0.7582
p.G169R	TCGA-DA-A1I1	SKCM	TCGA	VNTPLRS	DEG_SCF_FBW7_1	0.1667
p.G169R	DO37966	SKCM	ICGC	VNTPLRS	DEG_SCF_FBW7_1	0.1667
p.P151L	TCGA-EB-A5UL	SKCM	TCGA	VNTPLRS	DEG_SCF_FBW7_1	0.1667
p.P151L	DO47601	SKCM	ICGC	VNTPLRS	DEG_SCF_FBW7_1	0.1667
p.S168C	TCGA-MP-A4SV	LUAD	TCGA	VNTPLRS	DEG_SCF_FBW7_1	0.6389
p.S168C	DO45339	LUAD	ICGC	VNTPLRS	DEG_SCF_FBW7_1	0.6389
p.R150H	SIDM00569	Osteosarcoma	GDSC	VNTPLRS	DEG_SCF_FBW7_1	0.1389
p.R150H	SIDM00587	Biliary Tract Carcinoma	GDSC	VNTPLRS	DEG_SCF_FBW7_1	0.1389
p.R150H	SIDM01559	Melanoma	GDSC	VNTPLRS	DEG_SCF_FBW7_1	0.1389
p.R150H	SIDM01434	Hepatocellular Carcinoma	GDSC	VNTPLRS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08235	Mineralocorticoid receptor	DEG_SCF_FBW7_1	157:163	VNTPLRS	FBXW7	0.8321	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons