DegronMD

Uniprot ID: Q8N7K0

Source protein: Zinc finger protein 433

Source gene: ZNF433

Class: DEG_APCC_DBOX_1

Location: 62:70

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6225

ASA_SCORE: 100.5444

COIL: 0.6406

CONS_SCORE: 0.4151

DSS_SCORE: 0.1564

HELIX: 0.0272

FCONS_SCORE: 1.2408

RIG_SCORE: 0.8508

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y59H	TCGA-BR-8487	STAD	TCGA	LRRNLRIVG	DEG_APCC_DBOX_1	0.25
p.N61Y	TCGA-E6-A1LX	UCEC	TCGA	LRRNLRIVG	DEG_APCC_DBOX_1	0.3056
p.E70K	DO6320	CESC	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	0.7022
p.E70K	DO234400	ESAD	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	0.7022
p.E70K	DO222529	ESCA	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	0.7022
p.E70K	DO43907	UCEC	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	0.7022
p.E70K	DO41488	UCEC	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	0.7022
p.A80D	DO229036	LICA	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	0.0556
p.G65R	DO222837	MELA	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	0.7568
p.G78D	DO41235	UCEC	ICGC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1111
p.I55M	SIDM01020	Plasma Cell Myeloma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00570	Gastric Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00584	Osteosarcoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00291	Melanoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00544	Neuroblastoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01145	Gastric Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00592	Oral Cavity Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01181	Hepatocellular Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01196	Hepatocellular Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00487	Colorectal Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00292	Small Cell Lung Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00024	Non-Cancerous	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01653	Non-Cancerous	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00207	Glioblastoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00807	Bladder Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00018	Acute Myeloid Leukemia	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00988	Kidney Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00616	Hepatocellular Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00241	Breast Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00543	Melanoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00996	Thyroid Gland Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00381	Cervical Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM00531	Pancreatic Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01439	Hepatocellular Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01372	Pancreatic Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01335	Kidney Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01470	Acute Myeloid Leukemia	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01393	Gastric Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01377	Ovarian Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01573	Plasma Cell Myeloma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01347	Ovarian Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01658	Unknown	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01694	B-Lymphoblastic Leukemia	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01473	Plasma Cell Myeloma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.I55M	SIDM01343	Gastric Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.1389
p.R72I	SIDM01169	Ovarian Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.2778
p.R72I	ACH-000885	Ovarian Cancer	CCLE	LRRNLRIVG	DEG_APCC_DBOX_1	0.2778
p.R72I	TOV-21G	ovary	COSMIC	LRRNLRIVG	DEG_APCC_DBOX_1	0.2778
p.Y59C	SIDM01045	Endometrial Carcinoma	GDSC	LRRNLRIVG	DEG_APCC_DBOX_1	0.25
p.Y59C	ACH-000978	Endometrial/Uterine Cancer	CCLE	LRRNLRIVG	DEG_APCC_DBOX_1	0.25
p.Y59C	EN	endometrium	COSMIC	LRRNLRIVG	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRRNLRIVG

Degron related mutations and impact score

Drug responses associated with ZNF433 mutations

All proteins holding degron of LRRNLRIVG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7K0	Zinc finger protein 433	DEG_APCC_DBOX_1	62:70	LRRNLRIVG	APC,CDC20,FZR1	0.6225	More...