DegronMD

Uniprot ID: O94823

Source protein: Phospholipid-transporting ATPase VB

Source gene: ATP10B

Class: DEG_SCF_SKP2-CKS1_1

Location: 541:548

E3 ligase: SKP2,CSK1

DEGRON score: 0.9924

ASA_SCORE: 79.6875

COIL: 0.7244

CONS_SCORE: 0.5139

DSS_SCORE: 0.428

HELIX: 0.181

FCONS_SCORE: 1.0894

RIG_SCORE: 0.7453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K542N	TCGA-06-1805	GBM	TCGA	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.5806
p.K542N	DO11567	GBM	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.5806
p.K553E	TCGA-AP-A0LM	UCEC	TCGA	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.3056
p.K553E	DO43306	UCEC	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.3056
p.D547H	TCGA-BB-4227	HNSC	TCGA	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.6577
p.D547H	DO15855	HNSC	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.6577
p.V534A	TCGA-DD-AACX	LIHC	TCGA	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.1389
p.V534A	DO52215	LIHC	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.1389
p.E541K	TCGA-ER-A194	SKCM	TCGA	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.591
p.E541K	DO47646	SKCM	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.591
p.A558S	TCGA-OR-A5K8	ACC	TCGA	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.0556
p.D547E	DO233171	GACA	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.5647
p.K548N	DO233171	GACA	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.6918
p.A558V	DO50721	ORCA	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.0556
p.A558V	KYSE-220	oesophagus	COSMIC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.0556
p.I540T	SIDM00674	Non-Cancerous	GDSC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.3056
p.I540T	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.3056
p.I540T	SIDM00844	Burkitt's Lymphoma	GDSC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.3056
p.I540T	SIDM01664	Prostate Carcinoma	GDSC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.3056
p.I540T	SIDM01525	Acute Myeloid Leukemia	GDSC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94823	Phospholipid-transporting ATPase VB	DEG_SCF_SKP2-CKS1_1	541:548	EKDVTPDK	SKP2,CSK1	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons