DegronMD

Uniprot ID: Q8NDX5

Source protein: Polyhomeotic-like protein 3

Source gene: PHC3

Class: DEG_COP1_1

Location: 869:877

E3 ligase: COP1

DEGRON score: 0.9961

ASA_SCORE: 99.1889

COIL: 0.8193

CONS_SCORE: 0.4773

DSS_SCORE: 0.6518

HELIX: 0.1753

FCONS_SCORE: 1.0587

RIG_SCORE: 0.6439

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E883G	TCGA-AX-A06F	UCEC	TCGA	SHEDSVPSA	DEG_COP1_1	0.1667
p.L865F	TCGA-EE-A2MD	SKCM	TCGA	SHEDSVPSA	DEG_COP1_1	0.2222
p.S874C	TCGA-LN-A49M	ESCA	TCGA	SHEDSVPSA	DEG_COP1_1	0.7541
p.E887K	DO229018	LICA	ICGC	SHEDSVPSA	DEG_COP1_1	0.0556
p.E887K	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	SHEDSVPSA	DEG_COP1_1	0.0556
p.A859E	DO229019	LICA	ICGC	SHEDSVPSA	DEG_COP1_1	0.0556
p.E871G	DO41752	UCEC	ICGC	SHEDSVPSA	DEG_COP1_1	0.7199
p.A877V	CW-2	large_intestine	COSMIC	SHEDSVPSA	DEG_COP1_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDX5	Polyhomeotic-like protein 3	DEG_COP1_1	869:877	SHEDSVPSA	COP1	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons