DegronMD

Uniprot ID: Q5T011

Source protein: KICSTOR complex protein SZT2

Source gene: SZT2

Class: DEG_APCC_DBOX_1

Location: 2134:2142

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.53

ASA_SCORE: 84.6444

COIL: 0.7769

CONS_SCORE: 0.3079

DSS_SCORE: 0.6296

HELIX: 0.1874

FCONS_SCORE: 0.9487

RIG_SCORE: 0.6242

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K2145N	TCGA-17-Z000	LUAD	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	0.25
p.V2135I	TCGA-19-1787	GBM	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	0.7076
p.V2135I	SIDM02013	Colorectal Carcinoma	GDSC	PRSPLDMVS	DEG_APCC_DBOX_1	0.7076
p.L2124I	TCGA-AG-A002	READ	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	0.0556
p.L2124I	TCGA-BK-A6W3	UCEC	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	0.0556
p.L2124I	TCGA-EO-A3AV	UCEC	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	0.0556
p.R2127C	TCGA-BG-A18A	UCEC	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	0.5833
p.R2127C	TCGA-P5-A737	LGG	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	0.5833
p.A2131V	TCGA-VQ-A91D	STAD	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	0.25
p.R2138L	DO24265	LUAD	ICGC	PRSPLDMVS	DEG_APCC_DBOX_1	0.8428
p.R2138L	DO37619	SKCM	ICGC	PRSPLDMVS	DEG_APCC_DBOX_1	0.8428
p.R2138L	DO37806	SKCM	ICGC	PRSPLDMVS	DEG_APCC_DBOX_1	0.8428
p.R2138L	DO37474	SKCM	ICGC	PRSPLDMVS	DEG_APCC_DBOX_1	0.8428
p.H2142L	DO47555	SKCM	ICGC	PRSPLDMVS	DEG_APCC_DBOX_1	0.7313
p.V2151M	SIDM00572	Gastric Carcinoma	GDSC	PRSPLDMVS	DEG_APCC_DBOX_1	0.0833
p.V2151M	ACH-000911	Gastric Cancer	CCLE	PRSPLDMVS	DEG_APCC_DBOX_1	0.0833
p.V2151M	NUGC-3	stomach	COSMIC	PRSPLDMVS	DEG_APCC_DBOX_1	0.0833
p.E2130D	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PRSPLDMVS	DEG_APCC_DBOX_1	0.2222
p.E2130D	ACH-001669	Leukemia	CCLE	PRSPLDMVS	DEG_APCC_DBOX_1	0.2222
p.E2130D	ACH-002238	Leukemia	CCLE	PRSPLDMVS	DEG_APCC_DBOX_1	0.2222
p.E2130D	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PRSPLDMVS	DEG_APCC_DBOX_1	0.2222
p.C2144Y	SIDM00660	Colorectal Carcinoma	GDSC	PRSPLDMVS	DEG_APCC_DBOX_1	0.2778
p.C2144Y	ACH-000985	Colon/Colorectal Cancer	CCLE	PRSPLDMVS	DEG_APCC_DBOX_1	0.2778
p.C2144Y	LS-411N	large_intestine	COSMIC	PRSPLDMVS	DEG_APCC_DBOX_1	0.2778
p.R2142W	SIDM00217	Colorectal Carcinoma	GDSC	PRSPLDMVS	DEG_APCC_DBOX_1	0.8634
p.R2142W	ACH-000999	Colon/Colorectal Cancer	CCLE	PRSPLDMVS	DEG_APCC_DBOX_1	0.8634
p.R2142W	SNU-1040	large_intestine	COSMIC	PRSPLDMVS	DEG_APCC_DBOX_1	0.8634
p.P2137S	NCI-H1770	lung	COSMIC	PRSPLDMVS	DEG_APCC_DBOX_1	0.5641
p.P2137L	NCI-H1770	lung	COSMIC	PRSPLDMVS	DEG_APCC_DBOX_1	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSPLDMVS

Degron related mutations and impact score

Drug responses associated with SZT2 mutations

All proteins holding degron of PRSPLDMVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T011	KICSTOR complex protein SZT2	DEG_APCC_DBOX_1	2134:2142	PRSPLDMVS	APC,CDC20,FZR1	0.53	More...