DegronMD

Uniprot ID: P16070

Source protein: CD44 antigen

Source gene: CD44

Class: DEG_SPOP_SBC_1

Location: 635:639

E3 ligase: SPOP

DEGRON score: 0.7052

ASA_SCORE: 84.6

COIL: 0.9486

CONS_SCORE: 0.5101

DSS_SCORE: 0.7122

HELIX: 0.016

FCONS_SCORE: 0.9459

RIG_SCORE: 0.6028

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q635H	DO225367	BRCA	ICGC	ANTTS	DEG_SPOP_SBC_1	0.7582
p.G634V	DO228971	LICA	ICGC	ANTTS	DEG_SPOP_SBC_1	0.3056
p.R632S	DO229041	LICA	ICGC	ANTTS	DEG_SPOP_SBC_1	0.25
p.G629V	SIDM00928	Breast Carcinoma	GDSC	ANTTS	DEG_SPOP_SBC_1	0.1667
p.G629V	CAL-85-1	breast	COSMIC	ANTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16070	CD44 antigen	DEG_SPOP_SBC_1	635:639	ANTTS	SPOP	0.7052	More...
P32004	Neural cell adhesion molecule L1	DEG_SPOP_SBC_1	875:879	ANTTS	SPOP	0.8348	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	202:206	ANTTS	SPOP	0.6629	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons