DegronMD

Uniprot ID: P32004

Source protein: Neural cell adhesion molecule L1

Source gene: L1CAM

Class: DEG_SPOP_SBC_1

Location: 875:879

E3 ligase: SPOP

DEGRON score: 0.8348

ASA_SCORE: 61.7

COIL: 0.5972

CONS_SCORE: 0.3584

DSS_SCORE: 0.324

HELIX: 0.023

FCONS_SCORE: 0.7934

RIG_SCORE: 0.7814

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A875D	TCGA-33-4566	LUSC	TCGA	ANTTS	DEG_SPOP_SBC_1	0.7793
p.H870Y	TCGA-B6-A1KN	BRCA	TCGA	ANTTS	DEG_SPOP_SBC_1	0.1944
p.P874L	TCGA-EO-A22U	UCEC	TCGA	ANTTS	DEG_SPOP_SBC_1	0.3056
p.H865Y	DO3656	BRCA	ICGC	ANTTS	DEG_SPOP_SBC_1	0.0556
p.S884N	DO222735	BTCA	ICGC	ANTTS	DEG_SPOP_SBC_1	0.1944
p.P869S	DO233259	GACA	ICGC	ANTTS	DEG_SPOP_SBC_1	0.1667
p.R881W	DO233214	GACA	ICGC	ANTTS	DEG_SPOP_SBC_1	0.2778
p.P882T	DO229038	LICA	ICGC	ANTTS	DEG_SPOP_SBC_1	0.25
p.A870D	DO26790	LUSC	ICGC	ANTTS	DEG_SPOP_SBC_1	0.1944
p.L888M	DO50732	ORCA	ICGC	ANTTS	DEG_SPOP_SBC_1	0.0833
p.P869L	DO43755	UCEC	ICGC	ANTTS	DEG_SPOP_SBC_1	0.1667
p.Y888H	ACH-000848	Liver Cancer	CCLE	ANTTS	DEG_SPOP_SBC_1	0.0833
p.Y888H	JHH-7	liver	COSMIC	ANTTS	DEG_SPOP_SBC_1	0.0833
p.Y883H	JHH-7	liver	COSMIC	ANTTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16070	CD44 antigen	DEG_SPOP_SBC_1	635:639	ANTTS	SPOP	0.7052	More...
P32004	Neural cell adhesion molecule L1	DEG_SPOP_SBC_1	875:879	ANTTS	SPOP	0.8348	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	202:206	ANTTS	SPOP	0.6629	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons