DegronMD - P32004(L1CAM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A875D	TCGA-33-4566	LUSC	TCGA	ANTTS	DEG_SPOP_SBC_1	875:879	Mutation altering degron motif	0.7793
p.H870Y	TCGA-B6-A1KN	BRCA	TCGA	ANTTS	DEG_SPOP_SBC_1	875:879	Mutation rewiring degron network	0.1944
p.P874L	TCGA-EO-A22U	UCEC	TCGA	ANTTS	DEG_SPOP_SBC_1	875:879	Mutation rewiring degron network	0.3056
p.H865Y	DO3656	BRCA	ICGC	ANTTS	DEG_SPOP_SBC_1	875:879	Mutation rewiring degron network	0.0556
p.S884N	DO222735	BTCA	ICGC	ANTTS	DEG_SPOP_SBC_1	875:879	Mutation rewiring degron network	0.1944
p.P869S	DO233259	GACA	ICGC	ANTTS	DEG_SPOP_SBC_1	875:879	Mutation rewiring degron network	0.1667
p.R881W	DO233214	GACA	ICGC	ANTTS	DEG_SPOP_SBC_1	875:879	Mutation rewiring degron network	0.2778
p.P882T	DO229038	LICA	ICGC	ANTTS	DEG_SPOP_SBC_1	875:879	Mutation rewiring degron network	0.25
p.A870D	DO26790	LUSC	ICGC	ANTTS	DEG_SPOP_SBC_1	875:879	Mutation rewiring degron network	0.1944
p.L888M	DO50732	ORCA	ICGC	ANTTS	DEG_SPOP_SBC_1	875:879	Mutation rewiring degron network	0.0833
p.P869L	DO43755	UCEC	ICGC	ANTTS	DEG_SPOP_SBC_1	875:879	Mutation rewiring degron network	0.1667
p.Y888H	ACH-000848	Liver Cancer	CCLE	ANTTS	DEG_SPOP_SBC_1	875:879	Mutation rewiring degron network	0.0833
p.Y888H	JHH-7	liver	COSMIC	ANTTS	DEG_SPOP_SBC_1	875:879	Mutation rewiring degron network	0.0833
p.Y883H	JHH-7	liver	COSMIC	ANTTS	DEG_SPOP_SBC_1	875:879	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons