DegronMD

Uniprot ID: P16070

Source protein: CD44 antigen

Source gene: CD44

Class: DEG_SCF_FBW7_1

Location: 385:392

E3 ligase: FBXW7

DEGRON score: 0.6822

ASA_SCORE: 91.8625

COIL: 0.9345

CONS_SCORE: 0.3839

DSS_SCORE: 0.8143

HELIX: 0.0345

FCONS_SCORE: 0.8729

RIG_SCORE: 0.6233

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S391G	TCGA-33-6737	LUSC	TCGA	IQATPSST	DEG_SCF_FBW7_1	0.5882
p.S391G	DO26866	LUSC	ICGC	IQATPSST	DEG_SCF_FBW7_1	0.5882
p.Q399E	TCGA-85-8350	LUSC	TCGA	IQATPSST	DEG_SCF_FBW7_1	0.1389
p.Q399E	DO45492	LUSC	ICGC	IQATPSST	DEG_SCF_FBW7_1	0.1389
p.S391R	TCGA-DD-AAC8	LIHC	TCGA	IQATPSST	DEG_SCF_FBW7_1	0.6316
p.S391R	DO52193	LIHC	ICGC	IQATPSST	DEG_SCF_FBW7_1	0.6316
p.E401G	TCGA-KN-8430	KICH	TCGA	IQATPSST	DEG_SCF_FBW7_1	0.0833
p.E401G	DO220500	KICH	ICGC	IQATPSST	DEG_SCF_FBW7_1	0.0833
p.E376K	DO233212	GACA	ICGC	IQATPSST	DEG_SCF_FBW7_1	0.0833
p.S391I	DO229038	LICA	ICGC	IQATPSST	DEG_SCF_FBW7_1	0.623
p.S391I	DO229006	LICA	ICGC	IQATPSST	DEG_SCF_FBW7_1	0.623
p.S390T	SIDM01019	Acute Myeloid Leukemia	GDSC	IQATPSST	DEG_SCF_FBW7_1	0.6005
p.S390T	ACH-002258	Leukemia	CCLE	IQATPSST	DEG_SCF_FBW7_1	0.6005
p.S390T	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	IQATPSST	DEG_SCF_FBW7_1	0.6005
p.M396R	SNU-475	liver	COSMIC	IQATPSST	DEG_SCF_FBW7_1	0.2222
p.A390T	MFE-296	endometrium	COSMIC	IQATPSST	DEG_SCF_FBW7_1	0.7139
p.M394V	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	IQATPSST	DEG_SCF_FBW7_1	0.2778
p.S391N	CAL-51	breast	COSMIC	IQATPSST	DEG_SCF_FBW7_1	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16070	CD44 antigen	DEG_SCF_FBW7_1	385:392	IQATPSST	FBXW7	0.6822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons