DegronMD

Uniprot ID: Q92817

Source protein: Envoplakin

Source gene: EVPL

Class: CBL_PTK

Location: 355:364

E3 ligase: CBL

DEGRON score: 0.8064

ASA_SCORE: 82.8

COIL: 0.5688

CONS_SCORE: 0.3576

DSS_SCORE: 0.632

HELIX: 0.4182

FCONS_SCORE: 0.8767

RIG_SCORE: 0.6252

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A370T	TCGA-AX-A2HC	UCEC	TCGA	NLDAKYSPAP	CBL_PTK	0.1667
p.A370T	DO41572	UCEC	ICGC	NLDAKYSPAP	CBL_PTK	0.1667
p.G366A	TCGA-BG-A221	UCEC	TCGA	NLDAKYSPAP	CBL_PTK	0.2778
p.G366A	DO42384	UCEC	ICGC	NLDAKYSPAP	CBL_PTK	0.2778
p.G366A	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NLDAKYSPAP	CBL_PTK	0.2778
p.G366A	SIDM01263	T-Lymphoblastic Leukemia	GDSC	NLDAKYSPAP	CBL_PTK	0.2778
p.A370D	DO229008	LICA	ICGC	NLDAKYSPAP	CBL_PTK	0.1667
p.S346N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NLDAKYSPAP	CBL_PTK	0.5278
p.S346N	ACH-000995	Leukemia	CCLE	NLDAKYSPAP	CBL_PTK	0.5278
p.S346N	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	NLDAKYSPAP	CBL_PTK	0.5278
p.P364S	SIDM00864	Cervical Carcinoma	GDSC	NLDAKYSPAP	CBL_PTK	0.6752
p.P364S	ACH-001341	Cervical Cancer	CCLE	NLDAKYSPAP	CBL_PTK	0.6752
p.P364S	DoTc2-4510	cervix	COSMIC	NLDAKYSPAP	CBL_PTK	0.6752
p.S354F	ACH-001568	Skin Cancer	CCLE	NLDAKYSPAP	CBL_PTK	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92817	Envoplakin	CBL_PTK	355:364	NLDAKYSPAP	CBL	0.8064	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons