DegronMD

Uniprot ID: Q92817

Source protein: Envoplakin

Source gene: EVPL

Class: DEG_Kelch_Keap1_1

Location: 423:428

E3 ligase: KEAP1

DEGRON score: 0.5942

ASA_SCORE: 74.6

COIL: 0.651

CONS_SCORE: 0.4489

DSS_SCORE: 0.3809

HELIX: 0.1873

FCONS_SCORE: 1.107

RIG_SCORE: 0.7867

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q430K	TCGA-ES-A2HT	LIHC	TCGA	DWDSGE	DEG_Kelch_Keap1_1	0.2778
p.Q430K	DO22956	LIHC	ICGC	DWDSGE	DEG_Kelch_Keap1_1	0.2778
p.Q433R	DO229010	COCA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	0.1944
p.Q433R	DO229013	COCA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	0.1944
p.Q433R	DO229016	COCA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	0.1944
p.Q433R	DO229003	COCA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	0.1944
p.Q433R	DO229005	COCA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	0.1944
p.Q433R	DO230538	LUSC	ICGC	DWDSGE	DEG_Kelch_Keap1_1	0.1944
p.R436W	DO233823	GACA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	0.1111
p.R436W	DO220847	MELA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	0.1111
p.R436G	DO233293	NACA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	0.1111
p.G434D	DO232761	PBCA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	0.1667
p.R436Q	DO232998	PEME	ICGC	DWDSGE	DEG_Kelch_Keap1_1	0.1111
p.P415S	SIDM00997	Thyroid Gland Carcinoma	GDSC	DWDSGE	DEG_Kelch_Keap1_1	0.1111
p.P415S	SIDM00543	Melanoma	GDSC	DWDSGE	DEG_Kelch_Keap1_1	0.1111
p.P415S	SIDM01782	Oral Cavity Carcinoma	GDSC	DWDSGE	DEG_Kelch_Keap1_1	0.1111
p.P415S	8305C	thyroid	COSMIC	DWDSGE	DEG_Kelch_Keap1_1	0.1111
p.P415S	GAK	skin	COSMIC	DWDSGE	DEG_Kelch_Keap1_1	0.1111
p.W424L	SIDM00167	Head and Neck Carcinoma	GDSC	DWDSGE	DEG_Kelch_Keap1_1	0.5904
p.W424L	ACH-000715	Head and Neck Cancer	CCLE	DWDSGE	DEG_Kelch_Keap1_1	0.5904

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92817	Envoplakin	DEG_Kelch_Keap1_1	423:428	DWDSGE	KEAP1	0.5942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons