DegronMD

Uniprot ID: O14497

Source protein: AT-rich interactive domain-containing protein 1A

Source gene: ARID1A

Class: DEG_SCF_TRCP1_1

Location: 1315:1320

E3 ligase: BTRC

DEGRON score: 0.9973

ASA_SCORE: 79.65

COIL: 0.9388

CONS_SCORE: 0.4944

DSS_SCORE: 0.864

HELIX: 0.0457

FCONS_SCORE: 1.1123

RIG_SCORE: 0.5479

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1320Y	TCGA-AX-A0J0	UCEC	TCGA	DSGMYS	DEG_SCF_TRCP1_1	0.712
p.S1320Y	DO41133	UCEC	ICGC	DSGMYS	DEG_SCF_TRCP1_1	0.712
p.L1309I	TCGA-AX-A2HC	UCEC	TCGA	DSGMYS	DEG_SCF_TRCP1_1	0.1667
p.L1309I	DO41572	UCEC	ICGC	DSGMYS	DEG_SCF_TRCP1_1	0.1667
p.G1317W	TCGA-D1-A17C	UCEC	TCGA	DSGMYS	DEG_SCF_TRCP1_1	0.7825
p.G1317W	DO42841	UCEC	ICGC	DSGMYS	DEG_SCF_TRCP1_1	0.7825
p.P1321S	TCGA-DA-A1IC	SKCM	TCGA	DSGMYS	DEG_SCF_TRCP1_1	0.3056
p.P1321S	TCGA-FS-A1ZK	SKCM	TCGA	DSGMYS	DEG_SCF_TRCP1_1	0.3056
p.P1321S	DO220891	MELA	ICGC	DSGMYS	DEG_SCF_TRCP1_1	0.3056
p.P1321S	DO37474	SKCM	ICGC	DSGMYS	DEG_SCF_TRCP1_1	0.3056
p.P1321S	DO37430	SKCM	ICGC	DSGMYS	DEG_SCF_TRCP1_1	0.3056
p.R1323L	TCGA-NC-A5HH	LUSC	TCGA	DSGMYS	DEG_SCF_TRCP1_1	0.25
p.R1323L	DO219187	LUSC	ICGC	DSGMYS	DEG_SCF_TRCP1_1	0.25
p.P1305S	TCGA-VP-A87J	PRAD	TCGA	DSGMYS	DEG_SCF_TRCP1_1	0.0556
p.P1305S	DO51391	PRAD	ICGC	DSGMYS	DEG_SCF_TRCP1_1	0.0556
p.S1312Y	TCGA-ZF-A9RF	BLCA	TCGA	DSGMYS	DEG_SCF_TRCP1_1	0.25
p.S1312Y	DO219074	BLCA	ICGC	DSGMYS	DEG_SCF_TRCP1_1	0.25
p.P1326L	SIDM00837	Colorectal Carcinoma	GDSC	DSGMYS	DEG_SCF_TRCP1_1	0.1667
p.P1326L	ACH-000958	Colon/Colorectal Cancer	CCLE	DSGMYS	DEG_SCF_TRCP1_1	0.1667
p.P1321L	SIDM00502	B-Lymphoblastic Leukemia	GDSC	DSGMYS	DEG_SCF_TRCP1_1	0.3056
p.S1322G	SIDM00794	Other Solid Cancers	GDSC	DSGMYS	DEG_SCF_TRCP1_1	0.2778
p.S1322G	ACH-001442	Skin Cancer	CCLE	DSGMYS	DEG_SCF_TRCP1_1	0.2778
p.S1322G	A388	skin	COSMIC	DSGMYS	DEG_SCF_TRCP1_1	0.2778
p.P1307S	SIDM01608	Endometrial Carcinoma	GDSC	DSGMYS	DEG_SCF_TRCP1_1	0.1111
p.P1307S	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGMYS	DEG_SCF_TRCP1_1	0.1111
p.P1321R	ACH-001415	Bladder Cancer	CCLE	DSGMYS	DEG_SCF_TRCP1_1	0.3056
p.Y1324H	ACH-002340	Neuroblastoma	CCLE	DSGMYS	DEG_SCF_TRCP1_1	0.2222
p.Y1324H	NBsusSR	autonomic_ganglia	COSMIC	DSGMYS	DEG_SCF_TRCP1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGMYS

Degron related mutations and impact score

Drug responses associated with ARID1A mutations

All proteins holding degron of DSGMYS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SCF_TRCP1_1	1315:1320	DSGMYS	BTRC	0.9973	More...