DegronMD

Uniprot ID: O75157

Source protein: TSC22 domain family protein 2

Source gene: TSC22D2

Class: DEG_SCF_FBW7_1

Location: 628:635

E3 ligase: FBXW7

DEGRON score: 0.9515

ASA_SCORE: 79.075

COIL: 0.7944

CONS_SCORE: 0.3506

DSS_SCORE: 0.2738

HELIX: 0.1268

FCONS_SCORE: 0.8575

RIG_SCORE: 0.7587

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A625S	TCGA-86-8358	LUAD	TCGA	LQLTPMNS	DEG_SCF_FBW7_1	0.25
p.A625S	DO25471	LUAD	ICGC	LQLTPMNS	DEG_SCF_FBW7_1	0.25
p.N634S	TCGA-AX-A063	UCEC	TCGA	LQLTPMNS	DEG_SCF_FBW7_1	0.5958
p.N634S	DO42201	UCEC	ICGC	LQLTPMNS	DEG_SCF_FBW7_1	0.5958
p.A644S	TCGA-EO-A3KX	UCEC	TCGA	LQLTPMNS	DEG_SCF_FBW7_1	0.0833
p.A644S	DO219774	UCEC	ICGC	LQLTPMNS	DEG_SCF_FBW7_1	0.0833
p.A621V	ACH-001843	Bile Duct Cancer	CCLE	LQLTPMNS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75157	TSC22 domain family protein 2	DEG_SCF_FBW7_1	628:635	LQLTPMNS	FBXW7	0.9515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons