DegronMD

Uniprot ID: O75157

Source protein: TSC22 domain family protein 2

Source gene: TSC22D2

Class: DEG_SCF_TRCP1_1

Location: 215:221

E3 ligase: BTRC

DEGRON score: 0.9991

ASA_SCORE: 67.1

COIL: 0.8306

CONS_SCORE: 0.5077

DSS_SCORE: 0.442

HELIX: 0.0864

FCONS_SCORE: 1.2298

RIG_SCORE: 0.646

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D215H	TCGA-CD-8529	STAD	TCGA	DSGLGAT	DEG_SCF_TRCP1_1	0.7688
p.D215H	DO47753	STAD	ICGC	DSGLGAT	DEG_SCF_TRCP1_1	0.7688
p.T207A	DO35242	PACA	ICGC	DSGLGAT	DEG_SCF_TRCP1_1	0.5556
p.S206I	TCGA-A5-A0G2	UCEC	TCGA	DSGLGAT	DEG_SCF_TRCP1_1	0.5278
p.S206I	DO41235	UCEC	ICGC	DSGLGAT	DEG_SCF_TRCP1_1	0.5278
p.S205G	DO23178	LINC	ICGC	DSGLGAT	DEG_SCF_TRCP1_1	0.5
p.S205N	SIDM01689	B-Lymphoblastic Leukemia	GDSC	DSGLGAT	DEG_SCF_TRCP1_1	0.5
p.S205N	ACH-000492	Leukemia	CCLE	DSGLGAT	DEG_SCF_TRCP1_1	0.5
p.E213K	TCGA-91-6830	LUAD	TCGA	DSGLGAT	DEG_SCF_TRCP1_1	0.2778
p.E213K	DO25867	LUAD	ICGC	DSGLGAT	DEG_SCF_TRCP1_1	0.2778
p.V226A	TCGA-AX-A2HJ	UCEC	TCGA	DSGLGAT	DEG_SCF_TRCP1_1	0.1944
p.V226A	DO42105	UCEC	ICGC	DSGLGAT	DEG_SCF_TRCP1_1	0.1944

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75157	TSC22 domain family protein 2	DEG_SCF_TRCP1_1	215:221	DSGLGAT	BTRC	0.9991	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons