DegronMD

Uniprot ID: Q5SW79

Source protein: Centrosomal protein of 170 kDa

Source gene: CEP170

Class: DEG_APCC_DBOX_1

Location: 641:649

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9655

ASA_SCORE: 105.6556

COIL: 0.8439

CONS_SCORE: 0.482

DSS_SCORE: 0.7107

HELIX: 0.0644

FCONS_SCORE: 1.1836

RIG_SCORE: 0.6798

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L645H	TCGA-EE-A183	SKCM	TCGA	RRRTLPQLP	DEG_APCC_DBOX_1	0.7313
p.S641Y	DO52412	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.712
p.S641Y	DO41758	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.712
p.S641Y	DO41331	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.712
p.K649N	DO37356	READ	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.6918
p.T636I	DO41379	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.6389
p.E654Q	EPLC-272H	lung	COSMIC	RRRTLPQLP	DEG_APCC_DBOX_1	0.6389
p.R643Q	TCGA-AZ-4315	COAD	TCGA	RRRTLPQLP	DEG_APCC_DBOX_1	0.6218
p.R643Q	TCGA-C8-A131	BRCA	TCGA	RRRTLPQLP	DEG_APCC_DBOX_1	0.6218
p.K633N	DO41903	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.5556
p.E632Q	DO228607	GACA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.5278
p.K653R	SIDM01618	B-Lymphoblastic Leukemia	GDSC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3333
p.K653R	ACH-000942	Leukemia	CCLE	RRRTLPQLP	DEG_APCC_DBOX_1	0.3333
p.T640I	DO48401	BLCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO228483	BRCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO230334	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO224661	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO224761	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO222864	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO229010	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO229013	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO229016	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO229005	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO229480	LAML	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO51027	LAML	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SW79	Centrosomal protein of 170 kDa	DEG_APCC_DBOX_1	641:649	RRRTLPQLP	APC,CDC20,FZR1	0.9655	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons