DegronMD

Uniprot ID: Q5SW79

Source protein: Centrosomal protein of 170 kDa

Source gene: CEP170

Class: DEG_APCC_DBOX_1

Location: 641:649

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9655

ASA_SCORE: 105.6556

COIL: 0.8439

CONS_SCORE: 0.482

DSS_SCORE: 0.7107

HELIX: 0.0644

FCONS_SCORE: 1.1836

RIG_SCORE: 0.6798

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E656D	TCGA-AY-6196	COAD	TCGA	RRRTLPQLP	DEG_APCC_DBOX_1	0.1389
p.R643Q	TCGA-AZ-4315	COAD	TCGA	RRRTLPQLP	DEG_APCC_DBOX_1	0.6218
p.R643Q	TCGA-C8-A131	BRCA	TCGA	RRRTLPQLP	DEG_APCC_DBOX_1	0.6218
p.L645H	TCGA-EE-A183	SKCM	TCGA	RRRTLPQLP	DEG_APCC_DBOX_1	0.7313
p.T640I	DO48401	BLCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO228483	BRCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO230334	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO224661	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO224761	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO222864	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO229010	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO229013	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO229016	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO229005	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO229480	LAML	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.T640I	DO51027	LAML	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3056
p.E632Q	DO228607	GACA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.5278
p.Q655K	DO26560	LUSC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.1667
p.K649N	DO37356	READ	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.6918
p.A659V	DO37790	SKCM	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.0556
p.E657K	DO38439	STAD	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.1111
p.S641Y	DO52412	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.712
p.S641Y	DO41758	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.712
p.S641Y	DO41331	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.712
p.K633N	DO41903	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.5556
p.T636I	DO41379	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	0.6389
p.K653R	SIDM01618	B-Lymphoblastic Leukemia	GDSC	RRRTLPQLP	DEG_APCC_DBOX_1	0.3333
p.K653R	ACH-000942	Leukemia	CCLE	RRRTLPQLP	DEG_APCC_DBOX_1	0.3333
p.K638N	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	RRRTLPQLP	DEG_APCC_DBOX_1	0.25
p.R656K	K2	skin	COSMIC	RRRTLPQLP	DEG_APCC_DBOX_1	0.1389
p.E654Q	EPLC-272H	lung	COSMIC	RRRTLPQLP	DEG_APCC_DBOX_1	0.6389
p.Q651H	LCLC-103H	lung	COSMIC	RRRTLPQLP	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRTLPQLP

Degron related mutations and impact score

Drug responses associated with CEP170 mutations

All proteins holding degron of RRRTLPQLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SW79	Centrosomal protein of 170 kDa	DEG_APCC_DBOX_1	641:649	RRRTLPQLP	APC,CDC20,FZR1	0.9655	More...