DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DQETYSCKP
Uniprot ID:
Q5SW79
Source protein:
Centrosomal protein of 170 kDa
Source gene:
CEP170
Class:
CBL_PTK
Location:
1043:1051
E3 ligase:
CBL
DEGRON score:
0.9934
ASA_SCORE:
101.8222
COIL:
0.8614
CONS_SCORE:
0.4801
DSS_SCORE:
0.6062
HELIX:
0.1166
FCONS_SCORE:
1.0874
RIG_SCORE:
0.6619
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1034C
TCGA-29-1764
OV
TCGA
DQETYSCKP
CBL_PTK
0.5278
p.R1054W
TCGA-AP-A051
UCEC
TCGA
DQETYSCKP
CBL_PTK
0.25
p.D1043N
TCGA-CC-A3M9
LIHC
TCGA
DQETYSCKP
CBL_PTK
0.5821
p.R1054Q
TCGA-CM-5349
COAD
TCGA
DQETYSCKP
CBL_PTK
0.25
p.S1035C
DO218976
BLCA
ICGC
DQETYSCKP
CBL_PTK
0.1111
p.Q1054E
DO50023
BRCA
ICGC
DQETYSCKP
CBL_PTK
0.25
p.I1049V
DO1287
BRCA
ICGC
DQETYSCKP
CBL_PTK
0.7076
p.Q1054R
DO7828
COAD
ICGC
DQETYSCKP
CBL_PTK
0.25
p.R1056L
DO43378
UCEC
ICGC
DQETYSCKP
CBL_PTK
0.1944
p.S1035Y
DO43186
UCEC
ICGC
DQETYSCKP
CBL_PTK
0.1111
p.S1035Y
DO41572
UCEC
ICGC
DQETYSCKP
CBL_PTK
0.1111
p.R1044C
DO41211
UCEC
ICGC
DQETYSCKP
CBL_PTK
0.8301
p.R1044C
SNU-1040
large_intestine
COSMIC
DQETYSCKP
CBL_PTK
0.8301
p.R1048W
DO41331
UCEC
ICGC
DQETYSCKP
CBL_PTK
0.8634
p.R1048W
NCI-H2342
lung
COSMIC
DQETYSCKP
CBL_PTK
0.8634
p.A1060T
SIDM01090
Colorectal Carcinoma
GDSC
DQETYSCKP
CBL_PTK
0.0833
p.A1060T
ACH-000943
Colon/Colorectal Cancer
CCLE
DQETYSCKP
CBL_PTK
0.0833
p.A1060T
RKO
large_intestine
COSMIC
DQETYSCKP
CBL_PTK
0.0833
p.I1036F
SIDM00865
Small Cell Lung Carcinoma
GDSC
DQETYSCKP
CBL_PTK
0.1389
p.I1036F
ACH-000530
Lung Cancer
CCLE
DQETYSCKP
CBL_PTK
0.1389
p.I1036F
DMS-114
lung
COSMIC
DQETYSCKP
CBL_PTK
0.1389
p.K1038N
SNU-175
large_intestine
COSMIC
DQETYSCKP
CBL_PTK
0.1944
p.K1038R
GP5d
large_intestine
COSMIC
DQETYSCKP
CBL_PTK
0.1944
Drug responses associated with CEP170 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DQETYSCKP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5SW79
Centrosomal protein of 170 kDa
CBL_PTK
1043:1051
DQETYSCKP
CBL
0.9934
More...