DegronMD

Uniprot ID: O60281

Source protein: Zinc finger protein 292

Source gene: ZNF292

Class: DEG_SCF_TRCP1_1

Location: 1280:1285

E3 ligase: BTRC

DEGRON score: 0.9616

ASA_SCORE: 75.4333

COIL: 0.8377

CONS_SCORE: 0.6279

DSS_SCORE: 0.4937

HELIX: 0.1098

FCONS_SCORE: 1.0489

RIG_SCORE: 0.6117

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1293S	TCGA-L5-A8NI	ESCA	TCGA	DSGTNS	DEG_SCF_TRCP1_1	0.1111
p.E1291G	DO233888	GACA	ICGC	DSGTNS	DEG_SCF_TRCP1_1	0.1667
p.Q1295H	DO229025	LICA	ICGC	DSGTNS	DEG_SCF_TRCP1_1	0.0556
p.N1295S	DO50800	LIRI	ICGC	DSGTNS	DEG_SCF_TRCP1_1	0.0556
p.H1291Q	DO41542	UCEC	ICGC	DSGTNS	DEG_SCF_TRCP1_1	0.1667
p.E1291V	SIDM01944	Esophageal Carcinoma	GDSC	DSGTNS	DEG_SCF_TRCP1_1	0.1667
p.S1270T	SIDM01282	Colorectal Carcinoma	GDSC	DSGTNS	DEG_SCF_TRCP1_1	0.0556
p.F1287L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	DSGTNS	DEG_SCF_TRCP1_1	0.2778
p.F1287L	ACH-000960	Leukemia	CCLE	DSGTNS	DEG_SCF_TRCP1_1	0.2778
p.F1287L	REH	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTNS	DEG_SCF_TRCP1_1	0.2778
p.F1282L	REH	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTNS	DEG_SCF_TRCP1_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60281	Zinc finger protein 292	DEG_SCF_TRCP1_1	1280:1285	DSGTNS	BTRC	0.9616	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons