DegronMD

Uniprot ID: O60281

Source protein: Zinc finger protein 292

Source gene: ZNF292

Class: LIG_APCC_ABBA_1

Location: 645:650

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9397

ASA_SCORE: 101.8

COIL: 0.7977

CONS_SCORE: 0.5884

DSS_SCORE: 0.5515

HELIX: 0.0515

FCONS_SCORE: 0.9325

RIG_SCORE: 0.7972

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V647A	TCGA-A5-A0G2	UCEC	TCGA	FIVFND	LIG_APCC_ABBA_1	0.6936
p.V647A	DO41235	UCEC	ICGC	FIVFND	LIG_APCC_ABBA_1	0.6936
p.Y641C	TCGA-CD-8531	STAD	TCGA	FIVFND	LIG_APCC_ABBA_1	0.6667
p.D655N	TCGA-EO-A22U	UCEC	TCGA	FIVFND	LIG_APCC_ABBA_1	0.1944
p.D655N	DO43755	UCEC	ICGC	FIVFND	LIG_APCC_ABBA_1	0.1944
p.D651Y	DO228952	LICA	ICGC	FIVFND	LIG_APCC_ABBA_1	0.3056
p.D654Y	DO229045	LICA	ICGC	FIVFND	LIG_APCC_ABBA_1	0.6667
p.Y636C	DO47877	STAD	ICGC	FIVFND	LIG_APCC_ABBA_1	0.1944
p.F645V	SIDM00193	Colorectal Carcinoma	GDSC	FIVFND	LIG_APCC_ABBA_1	0.5957
p.F645V	ACH-000991	Colon/Colorectal Cancer	CCLE	FIVFND	LIG_APCC_ABBA_1	0.5957
p.F645V	SNU-81	large_intestine	COSMIC	FIVFND	LIG_APCC_ABBA_1	0.5957
p.F640V	SNU-81	large_intestine	COSMIC	FIVFND	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60281	Zinc finger protein 292	LIG_APCC_ABBA_1	645:650	FIVFND	APC,CDC20,FZR1	0.9397	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons