DegronMD

Uniprot ID: O60281

Source protein: Zinc finger protein 292

Source gene: ZNF292

Class: DEG_SCF_FBW7_1

Location: 1869:1876

E3 ligase: FBXW7

DEGRON score: 0.6897

ASA_SCORE: 91.575

COIL: 0.8244

CONS_SCORE: 0.6231

DSS_SCORE: 0.2165

HELIX: 0.0178

FCONS_SCORE: 1.4924

RIG_SCORE: 0.7796

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1870A	TCGA-AX-A1CE	UCEC	TCGA	LTPTPVKS	DEG_SCF_FBW7_1	0.6028
p.T1870A	DO42280	UCEC	ICGC	LTPTPVKS	DEG_SCF_FBW7_1	0.6028
p.P1873H	TCGA-EY-A215	UCEC	TCGA	LTPTPVKS	DEG_SCF_FBW7_1	0.7694
p.E1883Q	DO218976	BLCA	ICGC	LTPTPVKS	DEG_SCF_FBW7_1	0.1389
p.S1882F	DO47480	SKCM	ICGC	LTPTPVKS	DEG_SCF_FBW7_1	0.1667
p.P1868H	DO42665	UCEC	ICGC	LTPTPVKS	DEG_SCF_FBW7_1	0.3056
p.V1874D	SIDM00057	Neuroblastoma	GDSC	LTPTPVKS	DEG_SCF_FBW7_1	0.6674
p.V1874D	SIDM00552	Rhabdomyosarcoma	GDSC	LTPTPVKS	DEG_SCF_FBW7_1	0.6674
p.V1874D	ACH-000607	Rhabdoid	CCLE	LTPTPVKS	DEG_SCF_FBW7_1	0.6674
p.V1874D	KYM-1	soft_tissue	COSMIC	LTPTPVKS	DEG_SCF_FBW7_1	0.6674
p.T1870I	SIDM00516	Melanoma	GDSC	LTPTPVKS	DEG_SCF_FBW7_1	0.5966
p.T1870I	ACH-002166	Skin Cancer	CCLE	LTPTPVKS	DEG_SCF_FBW7_1	0.5966
p.T1870I	MZ7-mel	skin	COSMIC	LTPTPVKS	DEG_SCF_FBW7_1	0.5966
p.V1861L	SIDM01105	Melanoma	GDSC	LTPTPVKS	DEG_SCF_FBW7_1	0.1111
p.V1861L	ACH-000423	Skin Cancer	CCLE	LTPTPVKS	DEG_SCF_FBW7_1	0.1111
p.V1861L	SK-MEL-3	skin	COSMIC	LTPTPVKS	DEG_SCF_FBW7_1	0.1111
p.V1869D	KYM-1	soft_tissue	COSMIC	LTPTPVKS	DEG_SCF_FBW7_1	0.7785
p.T1865I	MZ7-mel	skin	COSMIC	LTPTPVKS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60281	Zinc finger protein 292	DEG_SCF_FBW7_1	1869:1876	LTPTPVKS	FBXW7	0.6897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons