DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPTPVKS
Uniprot ID:
O60281
Source protein:
Zinc finger protein 292
Source gene:
ZNF292
Class:
DEG_SCF_FBW7_1
Location:
1869:1876
E3 ligase:
FBXW7
DEGRON score:
0.6897
ASA_SCORE:
91.575
COIL:
0.8244
CONS_SCORE:
0.6231
DSS_SCORE:
0.2165
HELIX:
0.0178
FCONS_SCORE:
1.4924
RIG_SCORE:
0.7796
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V1869D
KYM-1
soft_tissue
COSMIC
LTPTPVKS
DEG_SCF_FBW7_1
0.7785
p.P1873H
TCGA-EY-A215
UCEC
TCGA
LTPTPVKS
DEG_SCF_FBW7_1
0.7694
p.V1874D
SIDM00057
Neuroblastoma
GDSC
LTPTPVKS
DEG_SCF_FBW7_1
0.6674
p.V1874D
SIDM00552
Rhabdomyosarcoma
GDSC
LTPTPVKS
DEG_SCF_FBW7_1
0.6674
p.V1874D
ACH-000607
Rhabdoid
CCLE
LTPTPVKS
DEG_SCF_FBW7_1
0.6674
p.V1874D
KYM-1
soft_tissue
COSMIC
LTPTPVKS
DEG_SCF_FBW7_1
0.6674
p.T1870A
TCGA-AX-A1CE
UCEC
TCGA
LTPTPVKS
DEG_SCF_FBW7_1
0.6028
p.T1870A
DO42280
UCEC
ICGC
LTPTPVKS
DEG_SCF_FBW7_1
0.6028
p.T1870I
SIDM00516
Melanoma
GDSC
LTPTPVKS
DEG_SCF_FBW7_1
0.5966
p.T1870I
ACH-002166
Skin Cancer
CCLE
LTPTPVKS
DEG_SCF_FBW7_1
0.5966
p.T1870I
MZ7-mel
skin
COSMIC
LTPTPVKS
DEG_SCF_FBW7_1
0.5966
p.P1868H
DO42665
UCEC
ICGC
LTPTPVKS
DEG_SCF_FBW7_1
0.3056
p.T1865I
MZ7-mel
skin
COSMIC
LTPTPVKS
DEG_SCF_FBW7_1
0.2222
p.S1882F
DO47480
SKCM
ICGC
LTPTPVKS
DEG_SCF_FBW7_1
0.1667
p.E1883Q
DO218976
BLCA
ICGC
LTPTPVKS
DEG_SCF_FBW7_1
0.1389
p.V1861L
SIDM01105
Melanoma
GDSC
LTPTPVKS
DEG_SCF_FBW7_1
0.1111
p.V1861L
ACH-000423
Skin Cancer
CCLE
LTPTPVKS
DEG_SCF_FBW7_1
0.1111
p.V1861L
SK-MEL-3
skin
COSMIC
LTPTPVKS
DEG_SCF_FBW7_1
0.1111
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Drug responses associated with ZNF292 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of LTPTPVKS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60281
Zinc finger protein 292
DEG_SCF_FBW7_1
1869:1876
LTPTPVKS
FBXW7
0.6897
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