DegronMD

Uniprot ID: P22670

Source protein: MHC class II regulatory factor RFX1

Source gene: RFX1

Class: DEG_SCF_FBW7_1

Location: 318:324

E3 ligase: FBXW7

DEGRON score: 0.9515

ASA_SCORE: 82.3714

COIL: 0.8371

CONS_SCORE: 0.3105

DSS_SCORE: 0.3468

HELIX: 0.0357

FCONS_SCORE: 1.0032

RIG_SCORE: 0.7726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T326M	TCGA-44-6144	LUAD	TCGA	PETPLYT	DEG_SCF_FBW7_1	0.2778
p.T326M	DO24190	LUAD	ICGC	PETPLYT	DEG_SCF_FBW7_1	0.2778
p.A327G	TCGA-86-8073	LUAD	TCGA	PETPLYT	DEG_SCF_FBW7_1	0.25
p.A327G	DO23624	LUAD	ICGC	PETPLYT	DEG_SCF_FBW7_1	0.25
p.R311H	DO233898	GACA	ICGC	PETPLYT	DEG_SCF_FBW7_1	0.1389
p.S330R	DO229029	LICA	ICGC	PETPLYT	DEG_SCF_FBW7_1	0.1667
p.L322M	DO232761	PBCA	ICGC	PETPLYT	DEG_SCF_FBW7_1	0.5999
p.I310M	DO229216	THCA	ICGC	PETPLYT	DEG_SCF_FBW7_1	0.1111
p.Q325R	DO229221	THCA	ICGC	PETPLYT	DEG_SCF_FBW7_1	0.3056
p.Q325H	DO229245	THCA	ICGC	PETPLYT	DEG_SCF_FBW7_1	0.3056
p.Q325E	SIDM01220	Glioma	GDSC	PETPLYT	DEG_SCF_FBW7_1	0.3056
p.Q325E	LNZTA3WT4	central_nervous_system	COSMIC	PETPLYT	DEG_SCF_FBW7_1	0.3056
p.S328N	ACH-001353	Pancreatic Cancer	CCLE	PETPLYT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22670	MHC class II regulatory factor RFX1	DEG_SCF_FBW7_1	318:324	PETPLYT	FBXW7	0.9515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons