DegronMD

Uniprot ID: Q15468

Source protein: SCL-interrupting locus protein

Source gene: STIL

Class: LIG_APCC_ABBA_1

Location: 1249:1254

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9211

ASA_SCORE: 68.6333

COIL: 0.6538

CONS_SCORE: 0.2698

DSS_SCORE: 0.6318

HELIX: 0.0858

FCONS_SCORE: 0.9383

RIG_SCORE: 0.7877

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1252T	TCGA-BR-7851	STAD	TCGA	ITIFPE	LIG_APCC_ABBA_1	0.7078
p.I1252T	DO38711	STAD	ICGC	ITIFPE	LIG_APCC_ABBA_1	0.7078
p.P1254T	TCGA-CA-6718	COAD	TCGA	ITIFPE	LIG_APCC_ABBA_1	0.7031
p.P1254T	DO7801	COAD	ICGC	ITIFPE	LIG_APCC_ABBA_1	0.7031
p.P1254S	TCGA-D3-A8GM	SKCM	TCGA	ITIFPE	LIG_APCC_ABBA_1	0.6752
p.P1254S	DO50288	SKCM	ICGC	ITIFPE	LIG_APCC_ABBA_1	0.6752
p.Q1258K	DO228971	LICA	ICGC	ITIFPE	LIG_APCC_ABBA_1	0.2222
p.H1241L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	ITIFPE	LIG_APCC_ABBA_1	0.1111
p.H1241L	ACH-000917	Esophageal Cancer	CCLE	ITIFPE	LIG_APCC_ABBA_1	0.1111
p.H1241L	TE-4	oesophagus	COSMIC	ITIFPE	LIG_APCC_ABBA_1	0.1111
p.F1241C	HCC2998	large_intestine	COSMIC	ITIFPE	LIG_APCC_ABBA_1	0.1111
p.K1239N	SNU-C5	large_intestine	COSMIC	ITIFPE	LIG_APCC_ABBA_1	0.0556
p.H1240L	TE-4	oesophagus	COSMIC	ITIFPE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15468	SCL-interrupting locus protein	LIG_APCC_ABBA_1	1249:1254	ITIFPE	APC,CDC20,FZR1	0.9211	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons