DegronMD

Uniprot ID: A4UGR9

Source protein: Xin actin-binding repeat-containing protein 2

Source gene: XIRP2

Class: DEG_APCC_KENBOX_2

Location: 2894:2898

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9799

ASA_SCORE: 125.7

COIL: 0.7322

CONS_SCORE: 0.4713

DSS_SCORE: 0.6938

HELIX: 0.2144

FCONS_SCORE: 1.2323

RIG_SCORE: 0.6938

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K2885N	TCGA-05-4398	LUAD	TCGA	QKENK	DEG_APCC_KENBOX_2	0.0833
p.K2885N	DO25847	LUAD	ICGC	QKENK	DEG_APCC_KENBOX_2	0.0833
p.E2900K	TCGA-19-5956	GBM	TCGA	QKENK	DEG_APCC_KENBOX_2	0.2778
p.E2900K	TCGA-AZ-6601	COAD	TCGA	QKENK	DEG_APCC_KENBOX_2	0.2778
p.E2900K	DO8119	COAD	ICGC	QKENK	DEG_APCC_KENBOX_2	0.2778
p.E2900K	DO13863	GBM	ICGC	QKENK	DEG_APCC_KENBOX_2	0.2778
p.E2900K	SIDM01611	Endometrial Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.2778
p.E2906D	TCGA-50-5939	LUAD	TCGA	QKENK	DEG_APCC_KENBOX_2	0.1111
p.E2906D	TCGA-EO-A3AV	UCEC	TCGA	QKENK	DEG_APCC_KENBOX_2	0.1111
p.E2906D	DO25183	LUAD	ICGC	QKENK	DEG_APCC_KENBOX_2	0.1111
p.E2906D	DO52412	UCEC	ICGC	QKENK	DEG_APCC_KENBOX_2	0.1111
p.K2902R	TCGA-55-8092	LUAD	TCGA	QKENK	DEG_APCC_KENBOX_2	0.2222
p.K2902R	TCGA-BL-A13I	BLCA	TCGA	QKENK	DEG_APCC_KENBOX_2	0.2222
p.K2902R	DO452	BLCA	ICGC	QKENK	DEG_APCC_KENBOX_2	0.2222
p.K2902R	DO26220	LUAD	ICGC	QKENK	DEG_APCC_KENBOX_2	0.2222
p.P2887S	TCGA-AZ-4315	COAD	TCGA	QKENK	DEG_APCC_KENBOX_2	0.1389
p.P2887S	DO8842	COAD	ICGC	QKENK	DEG_APCC_KENBOX_2	0.1389
p.P2887S	DO233823	GACA	ICGC	QKENK	DEG_APCC_KENBOX_2	0.1389
p.Q2905H	TCGA-BR-8360	STAD	TCGA	QKENK	DEG_APCC_KENBOX_2	0.1389
p.Q2905H	DO47745	STAD	ICGC	QKENK	DEG_APCC_KENBOX_2	0.1389
p.Q2888K	TCGA-EE-A3AA	SKCM	TCGA	QKENK	DEG_APCC_KENBOX_2	0.1667
p.Q2888K	DO37571	SKCM	ICGC	QKENK	DEG_APCC_KENBOX_2	0.1667
p.E2895A	TCGA-ER-A198	SKCM	TCGA	QKENK	DEG_APCC_KENBOX_2	0.7701
p.E2895A	DO47563	SKCM	ICGC	QKENK	DEG_APCC_KENBOX_2	0.7701
p.N2891H	TCGA-EY-A1GD	UCEC	TCGA	QKENK	DEG_APCC_KENBOX_2	0.25
p.N2891H	DO42129	UCEC	ICGC	QKENK	DEG_APCC_KENBOX_2	0.25
p.G2903D	DO228483	BRCA	ICGC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00305	Ovarian Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00993	Plasma Cell Myeloma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00615	Hepatocellular Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00075	Non-Cancerous	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01117	Small Cell Lung Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00491	Thyroid Gland Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00315	Glioblastoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00362	Burkitt's Lymphoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01189	Glioblastoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01112	Osteosarcoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00619	Thyroid Gland Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01093	Cervical Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00282	Colorectal Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00556	Neuroblastoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00251	Gastric Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00299	Other Sarcomas	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00214	Colorectal Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00580	Acute Myeloid Leukemia	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00561	Other Blood Cancers	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01061	Oral Cavity Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00566	Oral Cavity Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00560	Gastric Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00863	Burkitt's Lymphoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00316	Glioblastoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01033	Bladder Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01609	Endometrial Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01659	Kidney Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00165	Other Solid Cancers	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01682	Gastric Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01412	Oral Cavity Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00167	Head and Neck Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00166	Other Solid Cancers	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00160	Biliary Tract Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01471	Chronic Myelogenous Leukemia	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01573	Plasma Cell Myeloma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01435	Hepatocellular Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01774	Pancreatic Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01694	B-Lymphoblastic Leukemia	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01343	Gastric Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.E2896K	DO222880	MELA	ICGC	QKENK	DEG_APCC_KENBOX_2	0.7022
p.P2889A	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.1944
p.P2889A	NCI-H1838	lung	COSMIC	QKENK	DEG_APCC_KENBOX_2	0.1944
p.P2889Q	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.1944
p.P2889Q	NCI-H1838	lung	COSMIC	QKENK	DEG_APCC_KENBOX_2	0.1944
p.K2907E	SIDM01193	Glioma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.0833
p.K2907E	ACH-000040	Brain Cancer	CCLE	QKENK	DEG_APCC_KENBOX_2	0.0833
p.K2907E	U-118-MG	central_nervous_system	COSMIC	QKENK	DEG_APCC_KENBOX_2	0.0833
p.R2895H	BICR22	upper_aerodigestive_tract	COSMIC	QKENK	DEG_APCC_KENBOX_2	0.8244
p.E2893K	EKVX	lung	COSMIC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.K2890N	DU-145	prostate	COSMIC	QKENK	DEG_APCC_KENBOX_2	0.3333

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QKENK

Degron related mutations and impact score

Drug responses associated with XIRP2 mutations

All proteins holding degron of QKENK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_APCC_KENBOX_2	2894:2898	QKENK	APC,CDC20,FZR1	0.9799	More...