DegronMD

Uniprot ID: A4UGR9

Source protein: Xin actin-binding repeat-containing protein 2

Source gene: XIRP2

Class: DEG_APCC_KENBOX_2

Location: 2894:2898

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9799

ASA_SCORE: 125.7

COIL: 0.7322

CONS_SCORE: 0.4713

DSS_SCORE: 0.6938

HELIX: 0.2144

FCONS_SCORE: 1.2323

RIG_SCORE: 0.6938

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2895H	BICR22	upper_aerodigestive_tract	COSMIC	QKENK	DEG_APCC_KENBOX_2	0.8244
p.E2895A	TCGA-ER-A198	SKCM	TCGA	QKENK	DEG_APCC_KENBOX_2	0.7701
p.E2895A	DO47563	SKCM	ICGC	QKENK	DEG_APCC_KENBOX_2	0.7701
p.E2896K	DO222880	MELA	ICGC	QKENK	DEG_APCC_KENBOX_2	0.7022
p.K2890N	DU-145	prostate	COSMIC	QKENK	DEG_APCC_KENBOX_2	0.3333
p.G2903D	DO228483	BRCA	ICGC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00305	Ovarian Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00993	Plasma Cell Myeloma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00615	Hepatocellular Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00075	Non-Cancerous	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01117	Small Cell Lung Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00491	Thyroid Gland Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00315	Glioblastoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00362	Burkitt's Lymphoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01189	Glioblastoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01112	Osteosarcoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00619	Thyroid Gland Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM01093	Cervical Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00282	Colorectal Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00556	Neuroblastoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00251	Gastric Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056
p.G2903D	SIDM00299	Other Sarcomas	GDSC	QKENK	DEG_APCC_KENBOX_2	0.3056

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Drug responses associated with XIRP2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of QKENK

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_APCC_KENBOX_2	2894:2898	QKENK	APC,CDC20,FZR1	0.9799	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QKENK

Degron related mutations and impact score

Drug responses associated with XIRP2 mutations

All proteins holding degron of QKENK