DegronMD

Uniprot ID: A4UGR9

Source protein: Xin actin-binding repeat-containing protein 2

Source gene: XIRP2

Class: DEG_SCF_FBW7_2

Location: 173:180

E3 ligase: FBXW7

DEGRON score: 0.6495

ASA_SCORE: 88.025

COIL: 0.7345

CONS_SCORE: 0.4964

DSS_SCORE: 0.5026

HELIX: 0.1535

FCONS_SCORE: 0.9474

RIG_SCORE: 0.7594

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S180R	DO233850	GACA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.7427
p.S180T	DO228295	BRCA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.7116
p.E179K	TCGA-GN-A263	SKCM	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.7022
p.E179K	DO37766	SKCM	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.7022
p.D179N	YT	haematopoietic_and_lymphoid_tissue	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	0.5821
p.R184H	TCGA-DM-A28C	COAD	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.3333
p.R184H	DO7778	COAD	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.3333
p.R184C	TCGA-GU-A763	BLCA	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.3333
p.R184C	DO51888	BLCA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.3333
p.I181L	Sarc9371	bone	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	0.3056
p.H182D	TCGA-AR-A1AJ	BRCA	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.2778
p.H182D	DO4062	BRCA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.2778
p.H182Q	DO219873	SKCA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.2778
p.E170K	TCGA-D3-A3MV	SKCM	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.25
p.E170K	TCGA-FS-A1ZQ	SKCM	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.25
p.E170K	DO37727	SKCM	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.25
p.E170K	DO37442	SKCM	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.25
p.I185F	SIDM00704	Small Cell Lung Carcinoma	GDSC	VIDTPEDE	DEG_SCF_FBW7_2	0.1944
p.I185F	ACH-000639	Lung Cancer	CCLE	VIDTPEDE	DEG_SCF_FBW7_2	0.1944
p.I185F	NCI-H211	lung	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	0.1944
p.K167R	OE33	oesophagus	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	0.1667
p.E187D	TCGA-91-6848	LUAD	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.1389
p.E187D	DO23846	LUAD	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.1389
p.K166N	TCGA-CZ-4863	KIRC	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.1389
p.K166N	DO18691	KIRC	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.1389

Showing 1 to 25 of 36 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SCF_FBW7_2	173:180	VIDTPEDE	FBXW7	0.6495	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons