DegronMD

Uniprot ID: A4UGR9

Source protein: Xin actin-binding repeat-containing protein 2

Source gene: XIRP2

Class: DEG_SCF_FBW7_2

Location: 173:180

E3 ligase: FBXW7

DEGRON score: 0.6495

ASA_SCORE: 88.025

COIL: 0.7345

CONS_SCORE: 0.4964

DSS_SCORE: 0.5026

HELIX: 0.1535

FCONS_SCORE: 0.9474

RIG_SCORE: 0.7594

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D165Y	TCGA-64-5781	LUAD	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.1111
p.D165Y	DO23740	LUAD	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.1111
p.E187D	TCGA-91-6848	LUAD	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.1389
p.E187D	DO23846	LUAD	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.1389
p.H182D	TCGA-AR-A1AJ	BRCA	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.2778
p.H182D	DO4062	BRCA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.2778
p.K166N	TCGA-CZ-4863	KIRC	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.1389
p.K166N	DO18691	KIRC	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.1389
p.E170K	TCGA-D3-A3MV	SKCM	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.25
p.E170K	TCGA-FS-A1ZQ	SKCM	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.25
p.E170K	DO37727	SKCM	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.25
p.E170K	DO37442	SKCM	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.25
p.R184H	TCGA-DM-A28C	COAD	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.3333
p.R184H	DO7778	COAD	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.3333
p.D165E	TCGA-ED-A8O5	LIHC	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.1111
p.D165E	DO48558	LIHC	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.1111
p.E179K	TCGA-GN-A263	SKCM	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.7022
p.E179K	DO37766	SKCM	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.7022
p.R184C	TCGA-GU-A763	BLCA	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	0.3333
p.R184C	DO51888	BLCA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.3333
p.S180T	DO228295	BRCA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.7116
p.S180R	DO233850	GACA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.7427
p.V189L	DO228976	LICA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.0833
p.S164A	DO45243	LIRI	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.0833
p.H182Q	DO219873	SKCA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.2778
p.F190L	DO223286	UCEC	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	0.0556
p.V189M	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	VIDTPEDE	DEG_SCF_FBW7_2	0.0833
p.V189M	ACH-000825	Lung Cancer	CCLE	VIDTPEDE	DEG_SCF_FBW7_2	0.0833
p.V189M	HOP-92	lung	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	0.0833
p.I185F	SIDM00704	Small Cell Lung Carcinoma	GDSC	VIDTPEDE	DEG_SCF_FBW7_2	0.1944
p.I185F	ACH-000639	Lung Cancer	CCLE	VIDTPEDE	DEG_SCF_FBW7_2	0.1944
p.I185F	NCI-H211	lung	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	0.1944
p.L189S	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	0.0833
p.D179N	YT	haematopoietic_and_lymphoid_tissue	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	0.5821
p.K167R	OE33	oesophagus	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	0.1667
p.I181L	Sarc9371	bone	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VIDTPEDE

Degron related mutations and impact score

Drug responses associated with XIRP2 mutations

All proteins holding degron of VIDTPEDE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SCF_FBW7_2	173:180	VIDTPEDE	FBXW7	0.6495	More...