DegronMD

Uniprot ID: A4UGR9

Source protein: Xin actin-binding repeat-containing protein 2

Source gene: XIRP2

Class: DEG_APCC_DBOX_1

Location: 2775:2783

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6134

ASA_SCORE: 94.4444

COIL: 0.2191

CONS_SCORE: 0.7286

DSS_SCORE: 0.1809

HELIX: 0.7716

FCONS_SCORE: 1.2269

RIG_SCORE: 0.8398

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N2792S	TCGA-2Y-A9GZ	LIHC	TCGA	KREELQQIL	DEG_APCC_DBOX_1	0.0833
p.N2792S	DO219517	LIHC	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.0833
p.H2770R	TCGA-33-AAS8	LUSC	TCGA	KREELQQIL	DEG_APCC_DBOX_1	0.1944
p.H2770R	DO219123	LUSC	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.1944
p.I2789T	TCGA-43-3394	LUSC	TCGA	KREELQQIL	DEG_APCC_DBOX_1	0.1667
p.I2789T	DO26596	LUSC	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.1667
p.Q2793H	TCGA-AJ-A3EK	UCEC	TCGA	KREELQQIL	DEG_APCC_DBOX_1	0.0556
p.Q2793H	DO41584	UCEC	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.0556
p.V2782A	TCGA-B5-A11E	UCEC	TCGA	KREELQQIL	DEG_APCC_DBOX_1	0.6936
p.V2782A	DO41644	UCEC	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.6936
p.Q2793K	TCGA-EE-A2MQ	SKCM	TCGA	KREELQQIL	DEG_APCC_DBOX_1	0.0556
p.Q2793K	DO37810	SKCM	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.0556
p.Q2772P	TCGA-F5-6814	READ	TCGA	KREELQQIL	DEG_APCC_DBOX_1	0.25
p.Q2772P	DO36556	READ	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.25
p.V2782I	DO228483	BRCA	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.7076
p.V2782I	DO229010	COCA	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.7076
p.V2782I	DO229013	COCA	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.7076
p.V2782I	DO229003	COCA	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.7076
p.V2782I	DO229346	LAML	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.7076
p.V2782I	DO229505	LAML	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.7076
p.R2779G	DO228915	LICA	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.7568
p.L2784F	DO228976	LICA	ICGC	KREELQQIL	DEG_APCC_DBOX_1	0.3056
p.H2770Y	SIDM00656	Burkitt's Lymphoma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	0.1944
p.H2770Y	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	0.1944
p.H2770Y	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	0.1944
p.H2770Y	SIDM00641	Burkitt's Lymphoma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	0.1944
p.H2770Y	SIDM01664	Prostate Carcinoma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	0.1944
p.H2770Y	SIDM01409	Bladder Carcinoma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	0.1944
p.P2785A	SIDM00720	Mesothelioma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	0.2778
p.P2785A	ACH-000648	Lung Cancer	CCLE	KREELQQIL	DEG_APCC_DBOX_1	0.2778
p.P2785A	NCI-H28	pleura	COSMIC	KREELQQIL	DEG_APCC_DBOX_1	0.2778
p.L2784W	SIDM01450	Gastric Carcinoma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	0.3056
p.R2776H	OCUB-M	breast	COSMIC	KREELQQIL	DEG_APCC_DBOX_1	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KREELQQIL

Degron related mutations and impact score

Drug responses associated with XIRP2 mutations

All proteins holding degron of KREELQQIL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_APCC_DBOX_1	2775:2783	KREELQQIL	APC,CDC20,FZR1	0.6134	More...