DegronMD

Uniprot ID: Q8IZF6

Source protein: Adhesion G-protein coupled receptor G4

Source gene: ADGRG4

Class: DEG_SCF_FBW7_1

Location: 1339:1344

E3 ligase: FBXW7

DEGRON score: 0.9139

ASA_SCORE: 95.8333

COIL: 0.9402

CONS_SCORE: 0.781

DSS_SCORE: 0.5782

HELIX: 0.0122

FCONS_SCORE: 1.0163

RIG_SCORE: 0.6967

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1343S	SIDM00206	Glioblastoma	GDSC	ITPTLT	DEG_SCF_FBW7_1	0.6556
p.L1343S	D-566MG	central_nervous_system	COSMIC	ITPTLT	DEG_SCF_FBW7_1	0.6556
p.T1348R	SIDM00837	Colorectal Carcinoma	GDSC	ITPTLT	DEG_SCF_FBW7_1	0.2222
p.T1348R	SW48	large_intestine	COSMIC	ITPTLT	DEG_SCF_FBW7_1	0.2222
p.H1339P	MCC13	skin	COSMIC	ITPTLT	DEG_SCF_FBW7_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SCF_FBW7_1	1339:1344	ITPTLT	FBXW7	0.9139	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons