DegronMD

Uniprot ID: Q8IZF6

Source protein: Adhesion G-protein coupled receptor G4

Source gene: ADGRG4

Class: DEG_COP1_1

Location: 777:786

E3 ligase: COP1

DEGRON score: 0.7948

ASA_SCORE: 97.44

COIL: 0.9032

CONS_SCORE: 0.7798

DSS_SCORE: 0.3426

HELIX: 0.0135

FCONS_SCORE: 1.0225

RIG_SCORE: 0.7937

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P792T	huH-1	liver	COSMIC	TPRETVVPSV	DEG_COP1_1	0.1667
p.L790S	SK-GT-2	stomach	COSMIC	TPRETVVPSV	DEG_COP1_1	0.2222
p.T781R	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	TPRETVVPSV	DEG_COP1_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_COP1_1	777:786	TPRETVVPSV	COP1	0.7948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons