DegronMD

Uniprot ID: Q8IZF6

Source protein: Adhesion G-protein coupled receptor G4

Source gene: ADGRG4

Class: DEG_SPOP_SBC_1

Location: 384:388

E3 ligase: SPOP

DEGRON score: 0.856

ASA_SCORE: 86.68

COIL: 0.7724

CONS_SCORE: 0.7705

DSS_SCORE: 0.3243

HELIX: 0.0244

FCONS_SCORE: 1.0051

RIG_SCORE: 0.7614

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S386Y	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	VVSTT	DEG_SPOP_SBC_1	0.712
p.S386Y	NCI-H2126	lung	COSMIC	VVSTT	DEG_SPOP_SBC_1	0.712
p.R376H	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	VVSTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	384:388	VVSTT	SPOP	0.856	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons