DegronMD

Uniprot ID: Q8IZF6

Source protein: Adhesion G-protein coupled receptor G4

Source gene: ADGRG4

Class: DEG_SCF_FBW7_1

Location: 1982:1987

E3 ligase: FBXW7

DEGRON score: 0.9725

ASA_SCORE: 84.2

COIL: 0.9425

CONS_SCORE: 0.7923

DSS_SCORE: 0.3857

HELIX: 0.0107

FCONS_SCORE: 1.0568

RIG_SCORE: 0.746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1986I	SIDM01042	Breast Carcinoma	GDSC	VTPGTT	DEG_SCF_FBW7_1	0.5966
p.T1986I	EVSA-T	breast	COSMIC	VTPGTT	DEG_SCF_FBW7_1	0.5966
p.F1988Y	DB	haematopoietic_and_lymphoid_tissue	COSMIC	VTPGTT	DEG_SCF_FBW7_1	0.3056
p.L1973I	NCI-H835	lung	COSMIC	VTPGTT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SCF_FBW7_1	1982:1987	VTPGTT	FBXW7	0.9725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons