DegronMD

Uniprot ID: Q8IZF6

Source protein: Adhesion G-protein coupled receptor G4

Source gene: ADGRG4

Class: DEG_SCF_FBW7_1

Location: 584:589

E3 ligase: FBXW7

DEGRON score: 0.7424

ASA_SCORE: 98.9167

COIL: 0.8618

CONS_SCORE: 0.7949

DSS_SCORE: 0.3262

HELIX: 0.0205

FCONS_SCORE: 1.0231

RIG_SCORE: 0.8642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R581H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LTPEIT	DEG_SCF_FBW7_1	0.25
p.R581H	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	LTPEIT	DEG_SCF_FBW7_1	0.25
p.F594C	HCC2998	large_intestine	COSMIC	LTPEIT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SCF_FBW7_1	584:589	LTPEIT	FBXW7	0.7424	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons