DegronMD

Uniprot ID: Q8IZF6

Source protein: Adhesion G-protein coupled receptor G4

Source gene: ADGRG4

Class: DEG_COP1_1

Location: 1099:1106

E3 ligase: COP1

DEGRON score: 0.9411

ASA_SCORE: 93.05

COIL: 0.9221

CONS_SCORE: 0.7572

DSS_SCORE: 0.3488

HELIX: 0.0199

FCONS_SCORE: 0.9781

RIG_SCORE: 0.7514

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1097M	SIDM00373	Endometrial Carcinoma	GDSC	TSMAVPSL	DEG_COP1_1	0.2778
p.R1097M	SNG-M	endometrium	COSMIC	TSMAVPSL	DEG_COP1_1	0.2778
p.T1094K	NCI-H446	lung	COSMIC	TSMAVPSL	DEG_COP1_1	0.1944
p.G1095R	CP67-MEL	skin	COSMIC	TSMAVPSL	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_COP1_1	1099:1106	TSMAVPSL	COP1	0.9411	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons