DegronMD

Uniprot ID: Q8NET4

Source protein: Retrotransposon Gag-like protein 9

Source gene: RTL9

Class: DEG_SCF_TRCP1_1

Location: 303:309

E3 ligase: BTRC

DEGRON score: 0.9652

ASA_SCORE: 79.2

COIL: 0.8103

CONS_SCORE: 0.4037

DSS_SCORE: 0.5296

HELIX: 0.1149

FCONS_SCORE: 0.8287

RIG_SCORE: 0.7186

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S304F	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	DSGIMSS	DEG_SCF_TRCP1_1	0.7982
p.G293R	SIDM00522	Small Cell Lung Carcinoma	GDSC	DSGIMSS	DEG_SCF_TRCP1_1	0.0556
p.G293R	SIDM00140	Melanoma	GDSC	DSGIMSS	DEG_SCF_TRCP1_1	0.0556
p.G293R	DMS-273	lung	COSMIC	DSGIMSS	DEG_SCF_TRCP1_1	0.0556
p.G293R	COLO-792	skin	COSMIC	DSGIMSS	DEG_SCF_TRCP1_1	0.0556
p.G293E	SIDM00221	Melanoma	GDSC	DSGIMSS	DEG_SCF_TRCP1_1	0.0556

Showing 1 to 6 of 6 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SCF_TRCP1_1	303:309	DSGIMSS	BTRC	0.9652	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons