DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DSGAMST
Uniprot ID:
Q8NET4
Source protein:
Retrotransposon Gag-like protein 9
Source gene:
RTL9
Class:
DEG_SCF_TRCP1_1
Location:
407:413
E3 ligase:
BTRC
DEGRON score:
0.979
ASA_SCORE:
82.8714
COIL:
0.9196
CONS_SCORE:
0.457
DSS_SCORE:
0.5079
HELIX:
0.0544
FCONS_SCORE:
0.9293
RIG_SCORE:
0.6723
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V403G
SIDM00679
Cervical Carcinoma
GDSC
DSGAMST
DEG_SCF_TRCP1_1
0.2222
p.V403G
HT-3
cervix
COSMIC
DSGAMST
DEG_SCF_TRCP1_1
0.2222
p.P419T
SIDM01612
Endometrial Carcinoma
GDSC
DSGAMST
DEG_SCF_TRCP1_1
0.1667
Drug responses associated with RTL9 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGAMST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NET4
Retrotransposon Gag-like protein 9
DEG_SCF_TRCP1_1
407:413
DSGAMST
BTRC
0.979
More...